Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 107870..108405 | Replicon | plasmid pAPEC-O2-211A-ColV |
| Accession | NZ_CP030791 | ||
| Organism | Escherichia coli APEC O2-211 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | V0VJJ7 |
| Locus tag | APECO2_RS27225 | Protein ID | WP_000222760.1 |
| Coordinates | 107870..108157 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0VIP2 |
| Locus tag | APECO2_RS27230 | Protein ID | WP_001132900.1 |
| Coordinates | 108154..108405 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| APECO2_RS27185 | 103453..104674 | - | 1222 | Protein_98 | ISL3 family transposase | - |
| APECO2_RS27195 | 104774..105138 | + | 365 | Protein_99 | IS1 family transposase | - |
| APECO2_RS27200 | 105193..105975 | - | 783 | WP_001442137.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| APECO2_RS27205 | 105972..106994 | - | 1023 | WP_000255956.1 | IS21-like element IS100 family transposase | - |
| APECO2_RS27215 | 107083..107430 | + | 348 | Protein_102 | IS1-like element IS1A family transposase | - |
| APECO2_RS27225 | 107870..108157 | - | 288 | WP_000222760.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| APECO2_RS27230 | 108154..108405 | - | 252 | WP_001132900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| APECO2_RS27235 | 109368..110225 | - | 858 | WP_000774297.1 | incFII family plasmid replication initiator RepA | - |
| APECO2_RS27240 | 110218..110700 | - | 483 | WP_001273588.1 | hypothetical protein | - |
| APECO2_RS27245 | 110693..110767 | - | 75 | WP_001442103.1 | RepA leader peptide Tap | - |
| APECO2_RS27255 | 110999..111256 | - | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| APECO2_RS27260 | 111540..111746 | - | 207 | WP_001351576.1 | type I toxin-antitoxin system Hok family toxin | - |
| - | 111733..111794 | + | 62 | NuclAT_1 | - | - |
| - | 111733..111794 | + | 62 | NuclAT_1 | - | - |
| - | 111733..111794 | + | 62 | NuclAT_1 | - | - |
| - | 111733..111794 | + | 62 | NuclAT_1 | - | - |
| APECO2_RS28155 | 112050..112124 | - | 75 | Protein_110 | endonuclease | - |
| APECO2_RS27270 | 112370..112582 | - | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| APECO2_RS27275 | 112718..113278 | - | 561 | WP_000139315.1 | fertility inhibition protein FinO | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sitABCD | iroB / iroC / iroD / iroE / iroN / vat / vat / iutA / iucD / iucC / iucB / iucA | 1..197773 | 197773 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11105.15 Da Isoelectric Point: 10.5832
>T108063 WP_000222760.1 NZ_CP030791:c108157-107870 [Escherichia coli APEC O2-211]
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
Download Length: 288 bp
>T108063 NZ_CP030791:c108157-107870 [Escherichia coli APEC O2-211]
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9211.41 Da Isoelectric Point: 4.0780
>AT108063 WP_001132900.1 NZ_CP030791:c108405-108154 [Escherichia coli APEC O2-211]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
Download Length: 252 bp
>AT108063 NZ_CP030791:c108405-108154 [Escherichia coli APEC O2-211]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|