Detailed information of TA system TA108060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 4288164..4288964
• Replicon: chromosome
• Accession: NZ_CP030787
• Organism: Escherichia albertii strain 2013C-4143

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: B1EHN9
• Locus tag: CX698_RS21670
• Protein ID: WP_000342453.1
• Coordinates: 4288164..4288691 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: CX698_RS21675
• Protein ID: WP_001277104.1
• Coordinates: 4288698..4288964 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CX698_RS21645	4283239..4284006	-	768	WP_000083515.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
CX698_RS21650	4284003..4285280	-	1278	WP_113640797.1	branched chain amino acid ABC transporter permease LivM	-
CX698_RS21655	4285277..4286203	-	927	WP_001295097.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
CX698_RS21660	4286251..4287360	-	1110	WP_113640798.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
CX698_RS21665	4287784..4288167	+	384	WP_113640799.1	aspartate 1-decarboxylase autocleavage activator PanM	-
CX698_RS21670	4288164..4288691	-	528	WP_000342453.1	GNAT family N-acetyltransferase	Toxin
CX698_RS21675	4288698..4288964	-	267	WP_001277104.1	DUF1778 domain-containing protein	Antitoxin
CX698_RS21680	4289114..4290217	-	1104	WP_113640800.1	branched chain amino acid ABC transporter substrate-binding protein LivJ	-
CX698_RS21685	4290736..4291137	+	402	WP_001071334.1	PTS sugar transporter subunit IIA	-
CX698_RS21690	4291144..4291629	+	486	WP_000029260.1	PTS sugar transporter subunit IIB	-
CX698_RS21695	4291646..4292392	+	747	WP_000151889.1	PTS sugar transporter subunit IIC	-
CX698_RS21700	4292385..4293239	+	855	WP_000370584.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (88-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-86)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19676.58 Da
• Isoelectric Point: 6.9585

>T108060 WP_000342453.1 NZ_CP030787:c4288691-4288164 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Nucleotide

• Length: 528 bp

>T108060 NZ_CP030787:c4288691-4288164 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGCCGCAACACTC
CAGAACGTCAGGTCCTAGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9958.44 Da
• Isoelectric Point: 9.2519

>AT108060 WP_001277104.1 NZ_CP030787:c4288964-4288698 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNCASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Nucleotide

• Length: 267 bp

>AT108060 NZ_CP030787:c4288964-4288698 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACTGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA