Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3685929..3686580 Replicon chromosome
Accession NZ_CP030787
Organism Escherichia albertii strain 2013C-4143

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag CX698_RS18585 Protein ID WP_000244764.1
Coordinates 3685929..3686333 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CX698_RS18590 Protein ID WP_000354046.1
Coordinates 3686314..3686580 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CX698_RS18565 3681887..3683620 - 1734 WP_113640670.1 single-stranded-DNA-specific exonuclease RecJ -
CX698_RS18570 3683626..3684336 - 711 WP_000748105.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CX698_RS18575 3684361..3685257 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
CX698_RS18580 3685369..3685890 + 522 WP_001055879.1 flavodoxin FldB -
CX698_RS18585 3685929..3686333 - 405 WP_000244764.1 protein YgfX Toxin
CX698_RS18590 3686314..3686580 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CX698_RS18595 3686570..3686800 - 231 WP_000181267.1 hypothetical protein -
CX698_RS18600 3686832..3687812 + 981 WP_000886056.1 tRNA-modifying protein YgfZ -
CX698_RS18605 3688014..3688673 - 660 WP_000250281.1 hemolysin III family protein -
CX698_RS18610 3688841..3689152 - 312 WP_001182937.1 N(4)-acetylcytidine aminohydrolase -
CX698_RS18615 3689197..3690630 + 1434 WP_024164724.1 6-phospho-beta-glucosidase BglA -
CX698_RS18620 3690678..3691571 - 894 WP_113640671.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15887.87 Da        Isoelectric Point: 11.5439

>T108059 WP_000244764.1 NZ_CP030787:c3686333-3685929 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
KWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T108059 NZ_CP030787:c3686333-3685929 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
AAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGTGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT108059 WP_000354046.1 NZ_CP030787:c3686580-3686314 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT108059 NZ_CP030787:c3686580-3686314 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References