Detailed information of TA system TA108042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 78044..78579
• Replicon: plasmid unnamed3
• Accession: NZ_CP030786
• Organism: Escherichia albertii strain 2012EL-1823B

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8H9KAX0
• Locus tag: AYN53_RS25675
• Protein ID: WP_000222759.1
• Coordinates: 78292..78579 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8H9KB11
• Locus tag: AYN53_RS25670
• Protein ID: WP_001132891.1
• Coordinates: 78044..78295 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYN53_RS25645	73335..74312	-	978	WP_059276356.1	RepB family plasmid replication initiator protein	-
AYN53_RS25660	75393..76559	+	1167	WP_059278927.1	plasmid-partitioning protein SopA	-
AYN53_RS25665	76559..77530	+	972	WP_059278926.1	ParB/RepB/Spo0J family plasmid partition protein	-
AYN53_RS25670	78044..78295	+	252	WP_001132891.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AYN53_RS25675	78292..78579	+	288	WP_000222759.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AYN53_RS26180	78715..79612	+	898	Protein_75	transposase	-
AYN53_RS25690	79915..80628	-	714	WP_059278925.1	molecular chaperone	-
AYN53_RS25695	80625..81953	-	1329	WP_113650902.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	papD / papC / vat / papD / papC	1..105846	105846
	-	flank	IS/Tn	-	-	78773..79009	236

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11176.23 Da
• Isoelectric Point: 10.5832

>T108042 WP_000222759.1 NZ_CP030786:78292-78579 [Escherichia albertii]
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRELKNCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Nucleotide

• Length: 288 bp

>T108042 NZ_CP030786:78292-78579 [Escherichia albertii]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAGCAACAGTTCGC
AAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCTTCAGCAAAACTACGTGAACTAAAAAATTGCTACAAAATCA
AACTTCGTGCATCGGGTTTTCGTCTGGTCTATCAGGTTATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTTGCCAGCGAGAGAATGAGATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9181.39 Da
• Isoelectric Point: 4.0780

>AT108042 WP_001132891.1 NZ_CP030786:78044-78295 [Escherichia albertii]
MPNIILSDTSASVSELKKNPMATVGAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT108042 NZ_CP030786:78044-78295 [Escherichia albertii]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAACCCAATGGCAACAGTCGGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGAAACCAGCCGGCATTCTACTGTGTGCCTGCGGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGATCAGGAGCTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAT
AGTTATTTATGA