Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 68856..69631 Replicon plasmid unnamed3
Accession NZ_CP030786
Organism Escherichia albertii strain 2012EL-1823B

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag AYN53_RS25600 Protein ID WP_113650901.1
Coordinates 68856..69338 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag AYN53_RS25605 Protein ID WP_072146426.1
Coordinates 69329..69631 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYN53_RS25560 64030..64608 + 579 WP_059236323.1 hypothetical protein -
AYN53_RS25565 64725..65413 - 689 Protein_56 transposase -
AYN53_RS25570 65605..65886 - 282 WP_000780222.1 helix-turn-helix transcriptional regulator -
AYN53_RS25575 65867..66196 - 330 WP_113650899.1 type II toxin-antitoxin system RelE/ParE family toxin -
AYN53_RS25580 67132..67989 - 858 WP_124783371.1 incFII family plasmid replication initiator RepA -
AYN53_RS25585 67982..68056 - 75 WP_001365705.1 RepA leader peptide Tap -
AYN53_RS25595 68287..68544 - 258 WP_059278829.1 replication regulatory protein RepA -
AYN53_RS25600 68856..69338 - 483 WP_113650901.1 GNAT family N-acetyltransferase Toxin
AYN53_RS25605 69329..69631 - 303 WP_072146426.1 DUF1778 domain-containing protein Antitoxin
AYN53_RS25610 69951..70100 - 150 WP_072249360.1 type I toxin-antitoxin system Hok family toxin -
AYN53_RS25620 70164..71198 + 1035 Protein_65 transposase -
AYN53_RS25625 71208..71764 - 557 Protein_66 DDE-type integrase/transposase/recombinase -
AYN53_RS25630 71771..71973 - 203 Protein_67 IS110 family transposase -
AYN53_RS25635 72064..72189 + 126 WP_074458686.1 transcriptional regulator -
AYN53_RS25640 72310..73050 + 741 WP_001066942.1 tyrosine-type recombinase/integrase -
AYN53_RS25645 73335..74312 - 978 WP_059276356.1 RepB family plasmid replication initiator protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - papD / papC / vat / papD / papC 1..105846 105846


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-146)

Antitoxin

Vibrio phage ICP1, Orf50

(15-99)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17721.53 Da        Isoelectric Point: 7.0386

>T108041 WP_113650901.1 NZ_CP030786:c69338-68856 [Escherichia albertii]
MEINVTAPTLLTDEHILQPFDCGNEVLSNWLRGRAMKNQMLNASRTFVICLEGTLRVVGFYSLATGSVTHAELGRTLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVVNLAEQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPDTLFYKV

Download         Length: 483 bp

>T108041 NZ_CP030786:c69338-68856 [Escherichia albertii]
ATGGAAATAAATGTCACCGCGCCGACACTGCTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCCCGCACGTTCGTTATTTGTCTGGAGGGTA
CTTTACGTGTTGTGGGGTTCTACTCATTAGCTACGGGTTCCGTCACACATGCCGAGCTTGGGCGCACTTTGCGGCATAAC
ATGCCCAATCCTGTTCCTGTTGTTCTGTTAGGACGTCTGGCTGTCGATGTTTGTACCCAGGGACATGGTTTTGGTAAATG
GCTGCTAAGTGATGCTATTCACCGGGTTGTAAATCTGGCTGAGCAGGTTGGTATTAAGGCTGTTATGGTCCATGCAATTG
ATGATGACGCCAGAGCGTTTTATGAGCGTTTTGGTTTTGTCCAGTCAGTTGTGGCACCCGACACCTTATTTTATAAAGTC
TGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11648.21 Da        Isoelectric Point: 4.7174

>AT108041 WP_072146426.1 NZ_CP030786:c69631-69329 [Escherichia albertii]
MEVFMSTAASVRKTPRENQINIRATDEERAVIDYAASLVNKNRTDFIIELAYQEAKNIILDQRLFVLDNERYDSFITQLE
APVQNAEGRERLMAVKPEWK

Download         Length: 303 bp

>AT108041 NZ_CP030786:c69631-69329 [Escherichia albertii]
ATGGAGGTTTTTATGTCTACGGCTGCAAGCGTCCGTAAAACACCGCGAGAAAATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACTGATTTCATCATTGAACTGGCTTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGCTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAG
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References