Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 66562..67087 Replicon plasmid unnamed2
Accession NZ_CP030785
Organism Escherichia albertii strain 2012EL-1823B

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag AYN53_RS25195 Protein ID WP_113650864.1
Coordinates 66562..66867 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag AYN53_RS25200 Protein ID WP_113650865.1
Coordinates 66869..67087 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYN53_RS25160 61843..63112 + 1270 Protein_70 translesion error-prone DNA polymerase V subunit UmuC -
AYN53_RS25170 63117..63509 - 393 WP_000340830.1 plasmid partitioning/stability family protein -
AYN53_RS25175 63514..64485 - 972 WP_001103697.1 hypothetical protein -
AYN53_RS25180 64708..65352 + 645 WP_000633916.1 AAA family ATPase -
AYN53_RS25185 65346..65621 + 276 WP_000239529.1 hypothetical protein -
AYN53_RS25190 65752..66561 - 810 WP_113650863.1 site-specific integrase -
AYN53_RS25195 66562..66867 - 306 WP_113650864.1 type II toxin-antitoxin system toxin CcdB Toxin
AYN53_RS25200 66869..67087 - 219 WP_113650865.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
AYN53_RS25210 67683..67931 + 249 WP_113650866.1 hypothetical protein -
AYN53_RS25215 67919..68515 + 597 WP_113650867.1 hypothetical protein -
AYN53_RS26175 68804..69040 + 237 WP_205685739.1 ATP-binding cassette domain-containing protein -
AYN53_RS26050 69067..69255 + 189 WP_164508686.1 hypothetical protein -
AYN53_RS25220 69279..70109 + 831 WP_205685740.1 IS21-like element helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81130 81130
- flank IS/Tn - - 69180..70109 929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11687.47 Da        Isoelectric Point: 6.2213

>T108039 WP_113650864.1 NZ_CP030785:c66867-66562 [Escherichia albertii]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAHLLSDKVSRELYPVVHVGDESWRMMTTDMASVPISVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T108039 NZ_CP030785:c66867-66562 [Escherichia albertii]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTAGCCAGTGCCCACCTGCTGTCAGATAAGGTCTCCCGTGAACTTTACCCGGTGG
TGCATGTTGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGATCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8310.30 Da        Isoelectric Point: 5.0338

>AT108039 WP_113650865.1 NZ_CP030785:c67087-66869 [Escherichia albertii]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAVRWKAENQEGMAEVARFIEVNGSFADENRDW

Download         Length: 219 bp

>AT108039 NZ_CP030785:c67087-66869 [Escherichia albertii]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAAGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGTACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTTGCCCGGTTTATTGAAGTGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References