Detailed information of TA system TA108038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 16295..16920
• Replicon: plasmid unnamed2
• Accession: NZ_CP030785
• Organism: Escherichia albertii strain 2012EL-1823B

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AYN53_RS24830
• Protein ID: WP_089639806.1
• Coordinates: 16522..16920 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: AYN53_RS24825
• Protein ID: WP_089639807.1
• Coordinates: 16295..16522 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYN53_RS24820	13976..16162	-	2187	WP_112026771.1	type IV conjugative transfer system coupling protein TraD	-
AYN53_RS24825	16295..16522	+	228	WP_089639807.1	toxin-antitoxin system antitoxin VapB	Antitoxin
AYN53_RS24830	16522..16920	+	399	WP_089639806.1	tRNA(fMet)-specific endonuclease VapC	Toxin
AYN53_RS24835	16937..17440	-	504	WP_112026772.1	DUF2726 domain-containing protein	-
AYN53_RS24840	17447..18139	-	693	WP_021555347.1	hypothetical protein	-
AYN53_RS24845	18268..19005	-	738	WP_000926074.1	complement resistance protein TraT	-
AYN53_RS24850	19077..19727	-	651	WP_096935879.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..81130	81130

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14971.35 Da
• Isoelectric Point: 8.5187

>T108038 WP_089639806.1 NZ_CP030785:16522-16920 [Escherichia albertii]
MLKFMLDTNICIFTIKNKPAHIRERFNLNTGRMCISSVTVMELVYGAEKSQFPERNLAIIEGFISRLDVLNYDCAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERIAGLRLEDWC

Nucleotide

• Length: 399 bp

>T108038 NZ_CP030785:16522-16920 [Escherichia albertii]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACCATCAAAAATAAACCAGCGCATATCCGGGAGCGTTTCAA
TCTGAATACAGGGCGAATGTGCATCAGCTCAGTGACCGTGATGGAACTGGTATACGGTGCTGAAAAAAGTCAGTTTCCGG
AGCGTAATCTCGCGATTATCGAAGGATTTATTTCGCGTCTTGACGTACTGAATTATGACTGCGCTGCTGCCACACATACC
GGTCAGATCCGTGCTGAGCTCGCCCGTCAGGGACGTCCGGTGGGGCCATTTGACCAGATGATTGCCGGTCATGCCCGCAG
CAGGGGACTCATTGTGGTCACAAACAATACCCGGGAGTTTGAACGTATCGCCGGCCTTCGTCTGGAAGACTGGTGTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8396.41 Da
• Isoelectric Point: 4.3569

>AT108038 WP_089639807.1 NZ_CP030785:16295-16522 [Escherichia albertii]
METTVFLSNRSQAVRLPKAVALPEDVKKVDVIAVGRTRIITPAGESWDSWFDGDSVSADFMNDREQPAVQERDVF

Nucleotide

• Length: 228 bp

>AT108038 NZ_CP030785:16295-16522 [Escherichia albertii]
ATGGAAACGACCGTATTTCTCAGTAACCGGAGTCAGGCAGTCAGGCTGCCGAAGGCTGTAGCCCTGCCTGAAGACGTAAA
AAAAGTCGACGTTATTGCTGTTGGCCGTACCCGGATCATTACCCCGGCAGGAGAGTCCTGGGACAGCTGGTTCGATGGCG
ACAGTGTCAGCGCAGATTTCATGAATGACAGGGAACAACCCGCCGTACAGGAAAGGGACGTATTCTGA