Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3238195..3238846 Replicon chromosome
Accession NZ_CP030783
Organism Escherichia albertii strain 2012EL-1823B

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag AYN53_RS16530 Protein ID WP_000244763.1
Coordinates 3238195..3238599 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag AYN53_RS16535 Protein ID WP_000354046.1
Coordinates 3238580..3238846 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYN53_RS16510 3234153..3235886 - 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -
AYN53_RS16515 3235892..3236602 - 711 WP_113650364.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AYN53_RS16520 3236627..3237523 - 897 WP_059268127.1 site-specific tyrosine recombinase XerD -
AYN53_RS16525 3237635..3238156 + 522 WP_059221135.1 flavodoxin FldB -
AYN53_RS16530 3238195..3238599 - 405 WP_000244763.1 protein YgfX Toxin
AYN53_RS16535 3238580..3238846 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
AYN53_RS16540 3238836..3239066 - 231 WP_000181267.1 hypothetical protein -
AYN53_RS16545 3239098..3240078 + 981 WP_059221136.1 tRNA-modifying protein YgfZ -
AYN53_RS16550 3240280..3240939 - 660 WP_000250281.1 hemolysin III family protein -
AYN53_RS16555 3241107..3241418 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
AYN53_RS16560 3241463..3242896 + 1434 WP_164508673.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T108032 WP_000244763.1 NZ_CP030783:c3238599-3238195 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T108032 NZ_CP030783:c3238599-3238195 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT108032 WP_000354046.1 NZ_CP030783:c3238846-3238580 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT108032 NZ_CP030783:c3238846-3238580 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References