Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 9177..9958 Replicon plasmid unnamed
Accession NZ_CP030782
Organism Escherichia albertii strain 07-3866

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag CCF18_RS24490 Protein ID WP_125317893.1
Coordinates 9470..9958 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag CCF18_RS24485 Protein ID WP_001346256.1
Coordinates 9177..9479 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF18_RS24455 6389..7066 + 678 WP_125317890.1 type-F conjugative transfer system pilin acetylase TraX -
CCF18_RS24460 7121..7681 + 561 WP_125317891.1 fertility inhibition protein FinO -
CCF18_RS24465 7814..8026 + 213 WP_001311693.1 hypothetical protein -
CCF18_RS25260 8272..8361 + 90 Protein_7 endonuclease -
- 8602..8661 - 60 NuclAT_1 - -
- 8602..8661 - 60 NuclAT_1 - -
- 8602..8661 - 60 NuclAT_1 - -
- 8602..8661 - 60 NuclAT_1 - -
CCF18_RS24480 8706..8855 + 150 WP_001312851.1 type I toxin-antitoxin system Hok family toxin -
CCF18_RS24485 9177..9479 + 303 WP_001346256.1 DUF1778 domain-containing protein Antitoxin
CCF18_RS24490 9470..9958 + 489 WP_125317893.1 GNAT family N-acetyltransferase Toxin
CCF18_RS24495 10262..10522 + 261 WP_000078108.1 replication regulatory protein RepA -
CCF18_RS25170 10627..10786 + 160 Protein_12 protein CopA/IncA -
CCF18_RS24505 10756..10830 + 75 WP_125317928.1 RepA leader peptide Tap -
CCF18_RS24510 10823..11680 + 858 WP_125317895.1 incFII family plasmid replication initiator RepA -
CCF18_RS25175 12381..12536 + 156 WP_164512212.1 hypothetical protein -
CCF18_RS24525 12594..12863 + 270 WP_042021804.1 hypothetical protein -
CCF18_RS24530 12860..12994 + 135 Protein_17 type II toxin-antitoxin system RelE/ParE family toxin -
CCF18_RS25265 12974..13111 + 138 Protein_18 3'-5' exonuclease -
CCF18_RS24535 13072..13530 + 459 WP_125317897.1 hypothetical protein -
CCF18_RS24545 14286..14789 + 504 WP_125317898.1 type 1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - faeC / faeD / faeD / faeE / faeF / faeH / faeI / espL2 / espL2 / espL2 1..104269 104269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-149)

Antitoxin

Vibrio phage ICP1, Orf50

(15-99)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17909.76 Da        Isoelectric Point: 7.8823

>T108005 WP_125317893.1 NZ_CP030782:9470-9958 [Escherichia albertii]
MEINVTAPALLTDEHILQPFDCGNEVLSHWLHGRAMKNQMLNASRTFVICLEGTLRVVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVVKLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV
RG

Download         Length: 489 bp

>T108005 NZ_CP030782:9470-9958 [Escherichia albertii]
ATGGAAATAAATGTCACCGCACCGGCATTACTGACGGATGAGCATATACTTCAGCCATTTGATTGTGGGAATGAAGTGTT
AAGTCACTGGTTACATGGTCGCGCTATGAAAAACCAGATGCTCAATGCTTCCCGCACGTTCGTCATTTGCCTGGAGGGTA
CTTTACGTGTTGTGGGGTACTACTCATTAGCTACTGGTTCCGTCACTCATGCAGAGCTTGGGCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTTCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACTCAGGGGCATGGTTTTGGTAAATG
GCTGCTGAGTGATGCCATTCATCGGGTTGTCAAACTGGCTGATCAGGTTGGTATTAAGGCTGTTATGGTACATGCAATTG
ATGATGATGCCAGAGCGTTTTATGAGCGTTTTGGTTTTGTCCAGTCAGTAGTGGCACCCAATACCTTGTTTTATAAAGTC
CGAGGCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11602.19 Da        Isoelectric Point: 4.4569

>AT108005 WP_001346256.1 NZ_CP030782:9177-9479 [Escherichia albertii]
MEVVMPTTASIRKTPRENQINIRATDEERAVIDYAASLVNKNRTDFIIELAYQEAKNIILDQRLFVLDDECYDSFITQLE
APVQNAEGRERLMAVKPEWK

Download         Length: 303 bp

>AT108005 NZ_CP030782:9177-9479 [Escherichia albertii]
ATGGAGGTTGTTATGCCTACTACTGCAAGCATCCGTAAAACACCGCGAGAAAATCAGATTAACATCCGGGCAACGGATGA
GGAACGAGCTGTTATTGATTATGCCGCTAGCCTGGTCAATAAGAACCGTACTGATTTCATCATTGAACTGGCTTACCAGG
AAGCTAAAAACATCATCCTGGATCAACGTTTATTTGTGCTGGATGATGAATGTTATGATTCATTTATTACGCAACTTGAA
GCTCCTGTGCAGAATGCTGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References