Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2950748..2951399 Replicon chromosome
Accession NZ_CP030781
Organism Escherichia albertii strain 07-3866

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag CCF18_RS14760 Protein ID WP_000244763.1
Coordinates 2950748..2951152 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CCF18_RS14765 Protein ID WP_000354046.1
Coordinates 2951133..2951399 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF18_RS14740 2946711..2948444 - 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -
CCF18_RS14745 2948450..2949160 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CCF18_RS14750 2949185..2950081 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
CCF18_RS14755 2950193..2950714 + 522 WP_054410387.1 flavodoxin FldB -
CCF18_RS14760 2950748..2951152 - 405 WP_000244763.1 protein YgfX Toxin
CCF18_RS14765 2951133..2951399 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CCF18_RS14770 2951651..2952631 + 981 WP_059273222.1 tRNA-modifying protein YgfZ -
CCF18_RS14775 2952833..2953492 - 660 WP_000250281.1 hemolysin III family protein -
CCF18_RS14780 2953660..2953971 - 312 WP_125317623.1 N(4)-acetylcytidine aminohydrolase -
CCF18_RS14785 2954016..2955449 + 1434 WP_059273261.1 6-phospho-beta-glucosidase BglA -
CCF18_RS14790 2955497..2956390 - 894 WP_059214571.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T107992 WP_000244763.1 NZ_CP030781:c2951152-2950748 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T107992 NZ_CP030781:c2951152-2950748 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGTTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT107992 WP_000354046.1 NZ_CP030781:c2951399-2951133 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT107992 NZ_CP030781:c2951399-2951133 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAGTGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References