Detailed information of TA system TA107981

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 1384469..1385073
• Replicon: chromosome
• Accession: NZ_CP030781
• Organism: Escherichia albertii strain 07-3866

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A8H9EXF1
• Locus tag: CCF18_RS06810
• Protein ID: WP_059273620.1
• Coordinates: 1384469..1384855 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: B1ELZ9
• Locus tag: CCF18_RS06815
• Protein ID: WP_001195490.1
• Coordinates: 1384852..1385073 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCF18_RS06810	1384469..1384855	-	387	WP_059273620.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
CCF18_RS06815	1384852..1385073	-	222	WP_001195490.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CCF18_RS06820	1385491..1386249	+	759	WP_125317376.1	trans-aconitate 2-methyltransferase	-
CCF18_RS06825	1386253..1387167	-	915	WP_125317867.1	bestrophin family protein	-
CCF18_RS06830	1387372..1388823	-	1452	WP_105197997.1	tagaturonate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14475.47 Da
• Isoelectric Point: 8.0833

>T107981 WP_059273620.1 NZ_CP030781:c1384855-1384469 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MAFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Nucleotide

• Length: 387 bp

>T107981 NZ_CP030781:c1384855-1384469 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGGCCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8067.96 Da
• Isoelectric Point: 4.6816

>AT107981 WP_001195490.1 NZ_CP030781:c1385073-1384852 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Nucleotide

• Length: 222 bp

>AT107981 NZ_CP030781:c1385073-1384852 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A2S6PD20