Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 278790..279408 Replicon chromosome
Accession NZ_CP030781
Organism Escherichia albertii strain 07-3866

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CCF18_RS01390 Protein ID WP_001280991.1
Coordinates 278790..279008 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag CCF18_RS01395 Protein ID WP_000344798.1
Coordinates 279034..279408 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF18_RS01355 274080..274652 + 573 WP_000779847.1 YbaY family lipoprotein -
CCF18_RS01360 274682..274993 - 312 WP_000409915.1 MGMT family protein -
CCF18_RS01370 275374..275727 + 354 WP_125317203.1 DUF1428 family protein -
CCF18_RS01375 275765..277315 - 1551 WP_059273292.1 EAL domain-containing protein -
CCF18_RS01380 277479..277949 - 471 WP_000136188.1 YlaC family protein -
CCF18_RS01385 278056..278613 - 558 WP_025237467.1 maltose O-acetyltransferase -
CCF18_RS01390 278790..279008 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
CCF18_RS01395 279034..279408 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
CCF18_RS01400 279963..283112 - 3150 WP_001132500.1 multidrug efflux RND transporter permease subunit -
CCF18_RS01405 283135..284328 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T107980 WP_001280991.1 NZ_CP030781:c279008-278790 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T107980 NZ_CP030781:c279008-278790 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT107980 WP_000344798.1 NZ_CP030781:c279408-279034 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT107980 NZ_CP030781:c279408-279034 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References