Detailed information of TA system TA107968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 36059..36606
• Replicon: plasmid unnamed1
• Accession: NZ_CP030779
• Organism: Escherichia albertii strain 05-3106

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CYM74_RS23440
• Protein ID: WP_044718080.1
• Coordinates: 36059..36340 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: K4JYR0
• Locus tag: CYM74_RS23445
• Protein ID: WP_000079928.1
• Coordinates: 36337..36606 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYM74_RS23410	31678..32541	+	864	WP_000606641.1	helix-turn-helix domain-containing protein	-
CYM74_RS23415	33146..33523	-	378	WP_125296023.1	hypothetical protein	-
CYM74_RS24275	33583..33732	-	150	WP_002460893.1	hypothetical protein	-
CYM74_RS24340	33854..33970	+	117	Protein_37	ISL3 family transposase	-
CYM74_RS23430	34603..35085	-	483	WP_001311056.1	hypothetical protein	-
CYM74_RS23435	35202..36013	-	812	Protein_39	3'-5' exoribonuclease	-
CYM74_RS23440	36059..36340	-	282	WP_044718080.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CYM74_RS23445	36337..36606	-	270	WP_000079928.1	hypothetical protein	Antitoxin
CYM74_RS23455	37522..38379	-	858	WP_000130987.1	incFII family plasmid replication initiator RepA	-
CYM74_RS23460	38372..38446	-	75	WP_001365705.1	RepA leader peptide Tap	-
CYM74_RS23470	38684..38944	-	261	WP_000078108.1	replication regulatory protein RepA	-
CYM74_RS23475	39228..39434	-	207	WP_000876345.1	type I toxin-antitoxin system Hok family toxin	-
-	39426..39482	+	57	NuclAT_0	-	-
-	39426..39482	+	57	NuclAT_0	-	-
-	39426..39482	+	57	NuclAT_0	-	-
-	39426..39482	+	57	NuclAT_0	-	-
CYM74_RS23480	39723..39932	-	210	WP_024234785.1	hemolysin expression modulator Hha	-
CYM74_RS23485	39988..40224	-	237	WP_000376558.1	hypothetical protein	-
CYM74_RS23490	40311..41324	-	1014	WP_000118342.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	bfpF / bfpE / bfpD / bfpA	1..56603	56603

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10993.69 Da
• Isoelectric Point: 7.3153

>T107968 WP_044718080.1 NZ_CP030779:c36340-36059 [Escherichia albertii]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLVEQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Nucleotide

• Length: 282 bp

>T107968 NZ_CP030779:c36340-36059 [Escherichia albertii]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCTGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGTCGAGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10175.50 Da
• Isoelectric Point: 7.3210

>AT107968 WP_000079928.1 NZ_CP030779:c36606-36337 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT107968 NZ_CP030779:c36606-36337 [Escherichia albertii]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCCCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCACGGCGATGTGCTTCCCCATGACATGGTCGAATCCTCTGCTGCAGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A5W2J4D0