Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1640040..1640658 Replicon chromosome
Accession NZ_CP030778
Organism Escherichia albertii strain 05-3106

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CYM74_RS08220 Protein ID WP_001280991.1
Coordinates 1640440..1640658 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag CYM74_RS08215 Protein ID WP_113622883.1
Coordinates 1640040..1640414 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYM74_RS08205 1635120..1636313 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CYM74_RS08210 1636336..1639485 + 3150 WP_001132500.1 multidrug efflux RND transporter permease subunit -
CYM74_RS08215 1640040..1640414 + 375 WP_113622883.1 Hha toxicity modulator TomB Antitoxin
CYM74_RS08220 1640440..1640658 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
CYM74_RS08225 1640835..1641392 + 558 WP_025237467.1 maltose O-acetyltransferase -
CYM74_RS08230 1641499..1641969 + 471 WP_000136188.1 YlaC family protein -
CYM74_RS08235 1642133..1643683 + 1551 WP_054411428.1 EAL domain-containing protein -
CYM74_RS08240 1643721..1644074 - 354 WP_000878151.1 DUF1428 family protein -
CYM74_RS08250 1644455..1644766 + 312 WP_000409915.1 MGMT family protein -
CYM74_RS08255 1644796..1645368 - 573 WP_113622884.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T107950 WP_001280991.1 NZ_CP030778:1640440-1640658 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T107950 NZ_CP030778:1640440-1640658 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14500.34 Da        Isoelectric Point: 4.7295

>AT107950 WP_113622883.1 NZ_CP030778:1640040-1640414 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLADLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT107950 NZ_CP030778:1640040-1640414 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AGACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure

References