Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 928889..929370 | Replicon | chromosome |
| Accession | NZ_CP030778 | ||
| Organism | Escherichia albertii strain 05-3106 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7YS45 |
| Locus tag | CYM74_RS04725 | Protein ID | WP_014966210.1 |
| Coordinates | 929080..929370 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | A0A0D7Y007 |
| Locus tag | CYM74_RS04720 | Protein ID | WP_000100896.1 |
| Coordinates | 928889..929080 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CYM74_RS04665 | 923981..924244 | - | 264 | WP_000224221.1 | hypothetical protein | - |
| CYM74_RS04670 | 924246..924737 | - | 492 | WP_001167293.1 | hypothetical protein | - |
| CYM74_RS04675 | 924740..925099 | - | 360 | WP_001289987.1 | hypothetical protein | - |
| CYM74_RS24145 | 925096..925272 | - | 177 | WP_000753053.1 | hypothetical protein | - |
| CYM74_RS04680 | 925265..925447 | - | 183 | WP_001224665.1 | hypothetical protein | - |
| CYM74_RS04685 | 925576..925887 | - | 312 | WP_113622790.1 | hypothetical protein | - |
| CYM74_RS04690 | 925880..926134 | - | 255 | WP_000004324.1 | hypothetical protein | - |
| CYM74_RS04695 | 926131..926553 | - | 423 | WP_001151132.1 | DUF977 family protein | - |
| CYM74_RS04700 | 926594..927556 | - | 963 | WP_000095671.1 | helix-turn-helix domain-containing protein | - |
| CYM74_RS04705 | 927579..928004 | - | 426 | WP_000693845.1 | Rha family transcriptional regulator | - |
| CYM74_RS04710 | 927988..928263 | - | 276 | WP_001048458.1 | helix-turn-helix domain-containing protein | - |
| CYM74_RS04715 | 928371..928871 | + | 501 | WP_000824162.1 | helix-turn-helix transcriptional regulator | - |
| CYM74_RS04720 | 928889..929080 | + | 192 | WP_000100896.1 | hypothetical protein | Antitoxin |
| CYM74_RS04725 | 929080..929370 | + | 291 | WP_014966210.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CYM74_RS04730 | 929640..929792 | + | 153 | WP_021538048.1 | DUF1391 family protein | - |
| CYM74_RS04735 | 929804..930205 | + | 402 | WP_001339605.1 | hypothetical protein | - |
| CYM74_RS04740 | 930165..930443 | - | 279 | WP_000358771.1 | hypothetical protein | - |
| CYM74_RS04750 | 930991..932013 | + | 1023 | WP_000255946.1 | IS21-like element IS100 family transposase | - |
| CYM74_RS04755 | 932010..932792 | + | 783 | WP_001317493.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| CYM74_RS04760 | 932962..933150 | + | 189 | WP_000449172.1 | cell division inhibitor | - |
| CYM74_RS04765 | 933147..933335 | + | 189 | WP_000199480.1 | DUF1482 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 893636..944487 | 50851 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11176.05 Da Isoelectric Point: 9.9854
>T107949 WP_014966210.1 NZ_CP030778:929080-929370 [Escherichia albertii]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC
Download Length: 291 bp
>T107949 NZ_CP030778:929080-929370 [Escherichia albertii]
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGATGATTTACGTCAGATCGTAGCCTATATTGCTAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGTGAGATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGACAGTATCCAAACAAAACCTGTTAA
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGATGATTTACGTCAGATCGTAGCCTATATTGCTAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGTGAGATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGACAGTATCCAAACAAAACCTGTTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7033.83 Da Isoelectric Point: 4.0270
>AT107949 WP_000100896.1 NZ_CP030778:928889-929080 [Escherichia albertii]
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE
Download Length: 192 bp
>AT107949 NZ_CP030778:928889-929080 [Escherichia albertii]
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACAGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAAC
CAAAGTGGCAGCAAGCCTCTCAGATCCCCGTCCTGCAATTCCACATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTGCAACGAACAGGAGTGAGTAA
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACAGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAAC
CAAAGTGGCAGCAAGCCTCTCAGATCCCCGTCCTGCAATTCCACATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTGCAACGAACAGGAGTGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D7YS45 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D7Y007 |