Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1660169..1660878 Replicon chromosome
Accession NZ_CP030777
Organism Faecalibacterium prausnitzii strain APC918/95b

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C4Q21_RS08025 Protein ID WP_112114942.1
Coordinates 1660169..1660360 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C4Q21_RS08030 Protein ID WP_015538062.1
Coordinates 1660501..1660878 (+) Length 126 a.a.

Genomic Context

C4Q21_RS08020C4Q21_RS08025C4Q21_RS08030C4Q21_RS08055C4Q21_RS08015C4Q21_RS08035C4Q21_RS14630C4Q21_RS08045C4Q21_RS08050
Location: 1659754..1660056 (303 bp)
Type: Others
Protein ID: WP_097783627.1
Location: 1660169..1660360 (192 bp)
Type: Toxin
Protein ID: WP_112114942.1
Location: 1660501..1660878 (378 bp)
Type: Antitoxin
Protein ID: WP_015538062.1
Location: 1664550..1665626 (1077 bp)
Type: Others
Protein ID: WP_162789040.1
Location: 1657632..1659575 (1944 bp)
Type: Others
Protein ID: WP_113621122.1
Location: 1660955..1661722 (768 bp)
Type: Others
Protein ID: WP_113621123.1
Location: 1661754..1662101 (348 bp)
Type: Others
Protein ID: WP_205334566.1
Location: 1662271..1663905 (1635 bp)
Type: Others
Protein ID: WP_113621124.1
Location: 1663958..1664245 (288 bp)
Type: Others
Protein ID: WP_005923585.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4Q21_RS080151657632..1659575-1944WP_113621122.1Eco57I restriction-modification methylase domain-containing protein-
C4Q21_RS080201659754..1660056+303WP_097783627.1helix-turn-helix domain-containing protein-
C4Q21_RS080251660169..1660360+192WP_112114942.1type II toxin-antitoxin system HicA family toxinToxin
C4Q21_RS080301660501..1660878+378WP_015538062.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
C4Q21_RS080351660955..1661722-768WP_113621123.1hypothetical protein-
C4Q21_RS146301661754..1662101-348WP_205334566.1hypothetical protein-
C4Q21_RS080451662271..1663905-1635WP_113621124.1chaperonin GroEL-
C4Q21_RS080501663958..1664245-288WP_005923585.1co-chaperone GroES-
C4Q21_RS080551664550..1665626+1077WP_162789040.1acyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage-groEL1641054..166424523191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-114)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7076.36 Da        Isoelectric Point: 10.7682

>T107936 WP_112114942.1 NZ_CP030777:1660169-1660360 [Faecalibacterium prausnitzii]
MPMTPKQMIRLLEQNGFVLVSANGSHYKYHNPTTNKTTVVPFHAKDLKPGTEKNILKLAGLKK

Download         Length: 192 bp

>T107936 NZ_CP030777:1660169-1660360 [Faecalibacterium prausnitzii]
ATGCCGATGACTCCCAAGCAAATGATTCGCTTGCTGGAGCAGAACGGCTTTGTTTTAGTCAGTGCAAATGGGTCACACTA
CAAGTATCATAACCCAACTACCAACAAAACCACTGTCGTTCCATTTCACGCAAAGGATCTGAAGCCCGGTACCGAGAAAA
ATATTCTCAAATTAGCCGGACTCAAAAAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14002.94 Da        Isoelectric Point: 4.1445

>AT107936 WP_015538062.1 NZ_CP030777:1660501-1660878 [Faecalibacterium prausnitzii]
MNAIFYPAIFHPEETGYSVEIPDIEGCFTQGDTMDEAVRMAQDAIGLMLEDCKVCPEPSVPSALHVDPEDFVVMVPFDME
EYEKRYRPVKKTLSIPGWLNDAAESAHINFSGVLQDALKEKLHLA

Download         Length: 378 bp

>AT107936 NZ_CP030777:1660501-1660878 [Faecalibacterium prausnitzii]
ATGAACGCTATTTTCTATCCCGCAATTTTTCACCCGGAAGAAACCGGGTACTCTGTTGAGATTCCCGATATTGAGGGCTG
CTTCACCCAAGGCGATACCATGGACGAAGCCGTCCGTATGGCACAGGATGCCATCGGCCTTATGCTGGAAGATTGCAAAG
TCTGCCCGGAGCCTTCTGTCCCTTCTGCACTCCATGTTGATCCGGAAGATTTTGTGGTGATGGTGCCTTTCGATATGGAA
GAGTACGAAAAGCGGTACAGACCCGTAAAGAAAACCCTTTCCATTCCCGGCTGGCTCAACGATGCCGCCGAATCGGCACA
CATCAACTTTTCCGGCGTCCTTCAAGATGCGCTGAAAGAGAAACTCCATCTAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References