Detailed information of TA system TA107936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1660169..1660878
• Replicon: chromosome
• Accession: NZ_CP030777
• Organism: Faecalibacterium prausnitzii strain APC918/95b

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C4Q21_RS08025
• Protein ID: WP_112114942.1
• Coordinates: 1660169..1660360 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C4Q21_RS08030
• Protein ID: WP_015538062.1
• Coordinates: 1660501..1660878 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4Q21_RS08015	1657632..1659575	-	1944	WP_113621122.1	Eco57I restriction-modification methylase domain-containing protein	-
C4Q21_RS08020	1659754..1660056	+	303	WP_097783627.1	helix-turn-helix domain-containing protein	-
C4Q21_RS08025	1660169..1660360	+	192	WP_112114942.1	type II toxin-antitoxin system HicA family toxin	Toxin
C4Q21_RS08030	1660501..1660878	+	378	WP_015538062.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C4Q21_RS08035	1660955..1661722	-	768	WP_113621123.1	hypothetical protein	-
C4Q21_RS14630	1661754..1662101	-	348	WP_205334566.1	hypothetical protein	-
C4Q21_RS08045	1662271..1663905	-	1635	WP_113621124.1	chaperonin GroEL	-
C4Q21_RS08050	1663958..1664245	-	288	WP_005923585.1	co-chaperone GroES	-
C4Q21_RS08055	1664550..1665626	+	1077	WP_162789040.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	1641054..1664245	23191

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-114)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7076.36 Da
• Isoelectric Point: 10.7682

>T107936 WP_112114942.1 NZ_CP030777:1660169-1660360 [Faecalibacterium prausnitzii]
MPMTPKQMIRLLEQNGFVLVSANGSHYKYHNPTTNKTTVVPFHAKDLKPGTEKNILKLAGLKK

Nucleotide

• Length: 192 bp

>T107936 NZ_CP030777:1660169-1660360 [Faecalibacterium prausnitzii]
ATGCCGATGACTCCCAAGCAAATGATTCGCTTGCTGGAGCAGAACGGCTTTGTTTTAGTCAGTGCAAATGGGTCACACTA
CAAGTATCATAACCCAACTACCAACAAAACCACTGTCGTTCCATTTCACGCAAAGGATCTGAAGCCCGGTACCGAGAAAA
ATATTCTCAAATTAGCCGGACTCAAAAAGTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14002.94 Da
• Isoelectric Point: 4.1445

>AT107936 WP_015538062.1 NZ_CP030777:1660501-1660878 [Faecalibacterium prausnitzii]
MNAIFYPAIFHPEETGYSVEIPDIEGCFTQGDTMDEAVRMAQDAIGLMLEDCKVCPEPSVPSALHVDPEDFVVMVPFDME
EYEKRYRPVKKTLSIPGWLNDAAESAHINFSGVLQDALKEKLHLA

Nucleotide

• Length: 378 bp

>AT107936 NZ_CP030777:1660501-1660878 [Faecalibacterium prausnitzii]
ATGAACGCTATTTTCTATCCCGCAATTTTTCACCCGGAAGAAACCGGGTACTCTGTTGAGATTCCCGATATTGAGGGCTG
CTTCACCCAAGGCGATACCATGGACGAAGCCGTCCGTATGGCACAGGATGCCATCGGCCTTATGCTGGAAGATTGCAAAG
TCTGCCCGGAGCCTTCTGTCCCTTCTGCACTCCATGTTGATCCGGAAGATTTTGTGGTGATGGTGCCTTTCGATATGGAA
GAGTACGAAAAGCGGTACAGACCCGTAAAGAAAACCCTTTCCATTCCCGGCTGGCTCAACGATGCCGCCGAATCGGCACA
CATCAACTTTTCCGGCGTCCTTCAAGATGCGCTGAAAGAGAAACTCCATCTAGCATAA