Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1296547..1297112 Replicon chromosome
Accession NZ_CP030777
Organism Faecalibacterium prausnitzii strain APC918/95b

Toxin (Protein)


Gene name relE Uniprot ID C7H6P5
Locus tag C4Q21_RS06315 Protein ID WP_002596328.1
Coordinates 1296547..1296837 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7H6P4
Locus tag C4Q21_RS06320 Protein ID WP_005924829.1
Coordinates 1296834..1297112 (-) Length 93 a.a.

Genomic Context

C4Q21_RS06285C4Q21_RS06290C4Q21_RS06295C4Q21_RS06300C4Q21_RS06305C4Q21_RS06310C4Q21_RS06325C4Q21_RS06330C4Q21_RS06335C4Q21_RS06340C4Q21_RS06345C4Q21_RS06355C4Q21_RS06315C4Q21_RS06320C4Q21_RS06350
Location: 1292132..1292593 (462 bp)
Type: Others
Protein ID: WP_038259777.1
Location: 1293047..1293460 (414 bp)
Type: Others
Protein ID: WP_035394329.1
Location: 1293564..1294016 (453 bp)
Type: Others
Protein ID: WP_005933558.1
Location: 1294027..1294488 (462 bp)
Type: Others
Protein ID: WP_035394327.1
Location: 1294517..1294807 (291 bp)
Type: Others
Protein ID: WP_005933556.1
Location: 1294994..1296439 (1446 bp)
Type: Others
Protein ID: WP_007037415.1
Location: 1297239..1297637 (399 bp)
Type: Others
Protein ID: WP_005933550.1
Location: 1297751..1298485 (735 bp)
Type: Others
Protein ID: WP_015528455.1
Location: 1298482..1299345 (864 bp)
Type: Others
Protein ID: WP_015528456.1
Location: 1299389..1299583 (195 bp)
Type: Others
Protein ID: WP_002596333.1
Location: 1299661..1300026 (366 bp)
Type: Others
Protein ID: WP_015528457.1
Location: 1300846..1301913 (1068 bp)
Type: Others
Protein ID: WP_113621022.1
Location: 1296547..1296837 (291 bp)
Type: Toxin
Protein ID: WP_002596328.1
Location: 1296834..1297112 (279 bp)
Type: Antitoxin
Protein ID: WP_005924829.1
Location: 1300136..1300654 (519 bp)
Type: Others
Protein ID: WP_113621021.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4Q21_RS062851292132..1292593+462WP_038259777.1hypothetical protein-
C4Q21_RS062901293047..1293460+414WP_035394329.1hypothetical protein-
C4Q21_RS062951293564..1294016+453WP_005933558.1hypothetical protein-
C4Q21_RS063001294027..1294488+462WP_035394327.1sigma-70 family RNA polymerase sigma factor-
C4Q21_RS063051294517..1294807+291WP_005933556.1DUF3847 domain-containing protein-
C4Q21_RS063101294994..1296439+1446WP_007037415.1MobA/MobL family protein-
C4Q21_RS063151296547..1296837-291WP_002596328.1type II toxin-antitoxin system YafQ family toxinToxin
C4Q21_RS063201296834..1297112-279WP_005924829.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
C4Q21_RS063251297239..1297637+399WP_005933550.1cysteine-rich VLP domain-containing protein-
C4Q21_RS063301297751..1298485+735WP_015528455.1phage replisome organizer N-terminal domain-containing protein-
C4Q21_RS063351298482..1299345+864WP_015528456.1ATP-binding protein-
C4Q21_RS063401299389..1299583+195WP_002596333.1transposon-encoded TnpW family protein-
C4Q21_RS063451299661..1300026+366WP_015528457.1hypothetical protein-
C4Q21_RS063501300136..1300654-519WP_113621021.1GNAT family N-acetyltransferase-
C4Q21_RS063551300846..1301913+1068WP_113621022.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11112.87 Da        Isoelectric Point: 8.0630

>T107935 WP_002596328.1 NZ_CP030777:c1296837-1296547 [Faecalibacterium prausnitzii]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T107935 NZ_CP030777:c1296837-1296547 [Faecalibacterium prausnitzii]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAGGACTACAAACGAGCCATCAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGTCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTATCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10247.66 Da        Isoelectric Point: 4.4692

>AT107935 WP_005924829.1 NZ_CP030777:c1297112-1296834 [Faecalibacterium prausnitzii]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT107935 NZ_CP030777:c1297112-1296834 [Faecalibacterium prausnitzii]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACGGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTATTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1M4XBM1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1M4XB19

References