107893

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 910915..911750 Replicon chromosome
Accession NZ_CP030768
Organism Escherichia coli strain 2017C-4173W12

Toxin (Protein)


Gene name yeeV Uniprot ID S1PMM7
Locus tag DSB71_RS04510 Protein ID WP_000854720.1
Coordinates 911373..911750 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3B7PDS8
Locus tag DSB71_RS04505 Protein ID WP_001285612.1
Coordinates 910915..911283 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSB71_RS04460 905923..907461 - 1539 WP_000099193.1 IS66 family transposase -
DSB71_RS04465 907510..907857 - 348 WP_024173998.1 IS66 family insertion sequence element accessory protein TnpB -
DSB71_RS04470 907854..908258 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
DSB71_RS04475 908344..908577 + 234 WP_024173997.1 DUF905 family protein -
DSB71_RS04485 908677..909495 + 819 WP_047938428.1 DUF945 domain-containing protein -
DSB71_RS04490 909550..910035 + 486 WP_000849596.1 antirestriction protein -
DSB71_RS04495 910051..910527 + 477 WP_001747787.1 RadC family protein -
DSB71_RS04500 910614..910835 + 222 WP_000692347.1 DUF987 domain-containing protein -
DSB71_RS04505 910915..911283 + 369 WP_001285612.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DSB71_RS04510 911373..911750 + 378 WP_000854720.1 TA system toxin CbtA family protein Toxin
DSB71_RS04515 911747..912235 + 489 WP_000777672.1 hypothetical protein -
DSB71_RS04520 912247..912444 + 198 WP_000839238.1 DUF957 domain-containing protein -
DSB71_RS04525 912537..913403 + 867 WP_001290180.1 DUF4942 domain-containing protein -
DSB71_RS04530 913475..913738 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
DSB71_RS04535 913735..914061 + 327 WP_000779482.1 type II toxin-antitoxin system RelE/ParE family toxin -
DSB71_RS04540 914525..915790 + 1266 WP_001218868.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14089.02 Da        Isoelectric Point: 7.9087

>T107893 WP_000854720.1 NZ_CP030768:911373-911750 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T107893 NZ_CP030768:911373-911750 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13663.44 Da        Isoelectric Point: 6.0618

>AT107893 WP_001285612.1 NZ_CP030768:910915-911283 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSN
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT107893 NZ_CP030768:910915-911283 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGTACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAAT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FW05

Antitoxin

Source ID Structure
AlphaFold DB A0A3B7PDS8

References