Detailed information of TA system TA107884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 4854976..4855571
• Replicon: chromosome
• Accession: NZ_CP030767
• Organism: Escherichia coli strain 2017C-4109

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: U9Y4M4
• Locus tag: DSB73_RS26175
• Protein ID: WP_000239579.1
• Coordinates: 4855221..4855571 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: Q8XCF3
• Locus tag: DSB73_RS26170
• Protein ID: WP_001223210.1
• Coordinates: 4854976..4855227 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSB73_RS26160	4850641..4854420	+	3780	WP_120795364.1	autotransporter assembly complex protein TamB	-
DSB73_RS26165	4854423..4854764	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
DSB73_RS26170	4854976..4855227	+	252	WP_001223210.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
DSB73_RS26175	4855221..4855571	+	351	WP_000239579.1	endoribonuclease toxin ChpB	Toxin
DSB73_RS26180	4855651..4856181	-	531	WP_000055075.1	inorganic diphosphatase	-
DSB73_RS26185	4856491..4857447	+	957	WP_000265942.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
DSB73_RS26190	4857587..4859089	+	1503	Protein_4702	sugar ABC transporter ATP-binding protein	-
DSB73_RS26195	4859103..4860125	+	1023	WP_001301928.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12511.45 Da
• Isoelectric Point: 5.6219

>T107884 WP_000239579.1 NZ_CP030767:4855221-4855571 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T107884 NZ_CP030767:4855221-4855571 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9299.64 Da
• Isoelectric Point: 4.4201

>AT107884 WP_001223210.1 NZ_CP030767:4854976-4855227 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT107884 NZ_CP030767:4854976-4855227 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: A0A0E0Y8A8