Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3893177..3893977 Replicon chromosome
Accession NZ_CP030767
Organism Escherichia coli strain 2017C-4109

Toxin (Protein)


Gene name ataT Uniprot ID A0A891SNC1
Locus tag DSB73_RS21410 Protein ID WP_000342448.1
Coordinates 3893177..3893704 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag DSB73_RS21415 Protein ID WP_001277108.1
Coordinates 3893711..3893977 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSB73_RS21385 3888252..3889019 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
DSB73_RS21390 3889016..3890293 - 1278 WP_000803797.1 branched chain amino acid ABC transporter permease LivM -
DSB73_RS21395 3890290..3891216 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
DSB73_RS21400 3891264..3892373 - 1110 WP_001301528.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
DSB73_RS21405 3892797..3893180 + 384 WP_000778769.1 aspartate 1-decarboxylase autocleavage activator PanM -
DSB73_RS21410 3893177..3893704 - 528 WP_000342448.1 GNAT family N-acetyltransferase Toxin
DSB73_RS21415 3893711..3893977 - 267 WP_001277108.1 DUF1778 domain-containing protein Antitoxin
DSB73_RS21420 3894127..3895230 - 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
DSB73_RS21425 3895501..3896355 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
DSB73_RS21430 3896600..3897658 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
DSB73_RS21435 3897651..3898319 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(88-150)

Antitoxin

(8-86)


Sequences


Toxin        


Download         Length: 176 a.a.        Molecular weight: 19692.68 Da        Isoelectric Point: 7.3232

>T107879 WP_000342448.1 NZ_CP030767:c3893704-3893177 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

>T107879 NZ_CP030767:c3893704-3893177 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT107879 WP_001277108.1 NZ_CP030767:c3893977-3893711 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT107879 NZ_CP030767:c3893977-3893711 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6GTS


Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References