Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 287445..288138 Replicon plasmid unnamed3
Accession NZ_CP030763
Organism Rhizobium leguminosarum strain ATCC 14479

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag DLJ82_RS33670 Protein ID WP_112908051.1
Coordinates 287761..288138 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag DLJ82_RS33665 Protein ID WP_112908050.1
Coordinates 287445..287780 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ82_RS33640 282659..283576 - 918 WP_112908048.1 recombinase family protein -
DLJ82_RS33645 284101..285801 - 1701 WP_112908049.1 transposase -
DLJ82_RS33650 285861..286576 + 716 Protein_258 IS6 family transposase -
DLJ82_RS33655 286605..286934 - 330 Protein_259 transposase -
DLJ82_RS39795 286972..287363 + 392 Protein_260 IS5/IS1182 family transposase -
DLJ82_RS33665 287445..287780 - 336 WP_112908050.1 helix-turn-helix domain-containing protein Antitoxin
DLJ82_RS33670 287761..288138 - 378 WP_112908051.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DLJ82_RS33675 288549..288812 + 264 WP_112908052.1 hypothetical protein -
DLJ82_RS33680 288919..289977 - 1059 WP_162710388.1 alpha/beta fold hydrolase -
DLJ82_RS33685 290098..290919 + 822 WP_112908054.1 metallophosphatase family protein -
DLJ82_RS33690 291044..291520 - 477 WP_112908055.1 transposase -
DLJ82_RS33695 291594..291971 + 378 WP_112908056.1 hypothetical protein -
DLJ82_RS33700 292206..292415 + 210 WP_112908057.1 DUF3224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - gmd 1..771583 771583


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14158.36 Da        Isoelectric Point: 9.8338

>T107852 WP_112908051.1 NZ_CP030763:c288138-287761 [Rhizobium leguminosarum]
MIRDERPLEWIGSSYKDLMQLPVDVRKFIGFVLHFAQNGDQHPAAKVLKGFGSAGVLEVVENDVGGTYRAVYTVRFEEAV
FVLHCFQKKSKSGIATPKEDMDVIRARLKVAETVAKEMRHAHSRR

Download         Length: 378 bp

>T107852 NZ_CP030763:c288138-287761 [Rhizobium leguminosarum]
ATGATTCGAGATGAGCGTCCGCTTGAATGGATAGGTAGCAGCTACAAAGACCTGATGCAGCTTCCGGTCGATGTTCGGAA
GTTCATCGGCTTCGTGCTGCATTTCGCGCAGAACGGCGACCAGCATCCAGCGGCGAAGGTGCTCAAAGGCTTCGGCAGCG
CAGGCGTTCTCGAAGTGGTCGAGAACGATGTTGGTGGTACATATAGGGCTGTTTACACTGTCAGGTTTGAGGAAGCCGTG
TTCGTGCTTCACTGCTTCCAGAAGAAGAGCAAGAGCGGCATCGCCACACCGAAGGAAGATATGGACGTCATCCGGGCGCG
GCTCAAGGTTGCCGAGACTGTAGCAAAGGAGATGAGACATGCGCACTCGCGTCGTTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12138.10 Da        Isoelectric Point: 9.8595

>AT107852 WP_112908050.1 NZ_CP030763:c287780-287445 [Rhizobium leguminosarum]
MRTRVVDGIEVTTSSGNVFADLGLPHADKLKVKSGLMIEITKAVRRLDLTQEEAGRRMGLPQPKVSALLRGDFTNLSERK
LMDALNRLGYDIEITVRPTADPVGHLTLAVA

Download         Length: 336 bp

>AT107852 NZ_CP030763:c287780-287445 [Rhizobium leguminosarum]
ATGCGCACTCGCGTCGTTGATGGGATCGAGGTCACGACCAGCTCCGGCAATGTTTTTGCTGATCTTGGTTTGCCTCATGC
CGATAAGCTTAAAGTGAAATCCGGCCTGATGATCGAGATCACCAAGGCCGTGCGGCGGCTTGATCTCACGCAAGAGGAAG
CGGGGAGGCGCATGGGGCTTCCCCAGCCGAAGGTGTCTGCGCTCCTGCGCGGTGATTTCACGAACCTGTCAGAGCGTAAG
CTGATGGATGCCCTGAACCGGCTTGGCTACGATATCGAAATCACTGTGCGGCCTACGGCTGATCCAGTTGGGCACCTGAC
GCTTGCTGTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References