Detailed information of TA system TA107841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 95088..95616
• Replicon: plasmid unnamed1
• Accession: NZ_CP030755
• Organism: Acinetobacter schindleri strain H3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9N871
• Locus tag: DPR03_RS14780
• Protein ID: WP_000221358.1
• Coordinates: 95323..95616 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N9NWT9
• Locus tag: DPR03_RS14775
• Protein ID: WP_000246755.1
• Coordinates: 95088..95333 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DPR03_RS14750	90675..91094	+	420	Protein_89	recombinase family protein	-
DPR03_RS14760	91841..93652	+	1812	WP_034583971.1	copper resistance system multicopper oxidase	-
DPR03_RS14765	93639..93977	+	339	WP_004897649.1	hypothetical protein	-
DPR03_RS14770	93964..94908	+	945	WP_004668309.1	copper resistance protein B	-
DPR03_RS14775	95088..95333	+	246	WP_000246755.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DPR03_RS14780	95323..95616	+	294	WP_000221358.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DPR03_RS14785	95745..96074	-	330	WP_004641881.1	four-helix bundle copper-binding protein	-
DPR03_RS14790	96355..96816	-	462	Protein_96	IS3 family transposase	-
DPR03_RS14795	96896..98137	-	1242	WP_071321322.1	group II intron reverse transcriptase/maturase	-
DPR03_RS14805	98651..98770	-	120	Protein_98	IS3 family transposase	-
DPR03_RS14810	99036..99347	+	312	WP_071321321.1	BrnT family toxin	-
DPR03_RS14815	99310..99624	+	315	WP_071321320.1	BrnA antitoxin family protein	-
DPR03_RS15995	99695..99871	-	177	WP_164543112.1	hypothetical protein	-
DPR03_RS14820	99875..100039	-	165	Protein_102	IS4 family transposase	-
DPR03_RS14825	100110..100484	+	375	WP_005005993.1	succinate dehydrogenase, cytochrome b556 subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..223569	223569
	-	flank	IS/Tn	-	-	89917..90621	704

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-72)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11292.52 Da
• Isoelectric Point: 10.4753

>T107841 WP_000221358.1 NZ_CP030755:95323-95616 [Acinetobacter schindleri]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T107841 NZ_CP030755:95323-95616 [Acinetobacter schindleri]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9249.64 Da
• Isoelectric Point: 4.3142

>AT107841 WP_000246755.1 NZ_CP030755:95088-95333 [Acinetobacter schindleri]
MATVNFRIDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT107841 NZ_CP030755:95088-95333 [Acinetobacter schindleri]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Structures

Toxin

• AlphaFold DB: A0A6A1RKP4

Antitoxin

• AlphaFold DB: A0A6A1RJ80