Detailed information of TA system TA107838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2010396..2011024
• Replicon: chromosome
• Accession: NZ_CP030753
• Organism: Actinobacillus pleuropneumoniae strain S4074

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DRF63_RS09475
• Protein ID: WP_005599242.1
• Coordinates: 2010626..2011024 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A828PGB0
• Locus tag: DRF63_RS09470
• Protein ID: WP_005599241.1
• Coordinates: 2010396..2010626 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DRF63_RS09465	2008369..2009955	+	1587	WP_005599240.1	DUF262 domain-containing protein	-
DRF63_RS09470	2010396..2010626	+	231	WP_005599241.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DRF63_RS09475	2010626..2011024	+	399	WP_005599242.1	tRNA(fMet)-specific endonuclease VapC	Toxin
DRF63_RS09480	2011159..2011575	-	417	WP_005599244.1	DUF417 family protein	-
DRF63_RS09485	2011812..2013002	-	1191	WP_005599245.1	pentapeptide repeat-containing protein	-
DRF63_RS09490	2013055..2014377	-	1323	WP_005620148.1	HslU--HslV peptidase ATPase subunit	-
DRF63_RS09495	2014523..2015044	-	522	WP_005599247.1	ATP-dependent protease subunit HslV	-
DRF63_RS09500	2015122..2015833	-	712	Protein_1818	DNA/RNA nuclease SfsA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1995017..2013002	17985

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (6-52)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15028.31 Da
• Isoelectric Point: 7.4716

>T107838 WP_005599242.1 NZ_CP030753:2010626-2011024 [Actinobacillus pleuropneumoniae]
MLTYMLDTNIAIYVIKRRPLEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPEQNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKHGKIIGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLANWV

Nucleotide

• Length: 399 bp

>T107838 NZ_CP030753:2010626-2011024 [Actinobacillus pleuropneumoniae]
ATGCTGACTTATATGCTTGATACTAACATTGCGATTTATGTCATTAAACGCAGACCACTTGAAGTGCTGGATAAGTTTAA
TTTAAATTCCACCCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGCTGTATTATGGGGCAGAGAAAAGCCAGTTTCCGG
AACAGAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGCACGGTAAGATTATCGGGGAGAACGATATTCACATTGCCGCACATGCAAGAAG
TGAAGGACTCGTATTAGTAACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTACGATTAGCTAATTGGGTATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8561.71 Da
• Isoelectric Point: 4.7063

>AT107838 WP_005599241.1 NZ_CP030753:2010396-2010626 [Actinobacillus pleuropneumoniae]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISIQPEREGL

Nucleotide

• Length: 231 bp

>AT107838 NZ_CP030753:2010396-2010626 [Actinobacillus pleuropneumoniae]
ATGGAAGCATCGGTATTTATGACAAACCGTAGTCAAGCGGTACGATTGCCGGCAGAAGTACGCTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTAGTCGGTAATGAGCGTATTTTGGCTCCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGGT
CGGCAACGGTAAGCGATGATTTCATGACAGAGCGTGAAATCAGCATTCAGCCCGAACGTGAGGGACTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A828PGB0