Detailed information of TA system TA107837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1796968..1797699
• Replicon: chromosome
• Accession: NZ_CP030753
• Organism: Actinobacillus pleuropneumoniae strain S4074

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: DRF63_RS08405
• Protein ID: WP_005598840.1
• Coordinates: 1796968..1797435 (-)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: B0BRD3
• Locus tag: DRF63_RS08410
• Protein ID: WP_005619269.1
• Coordinates: 1797439..1797699 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DRF63_RS08380	1792327..1792698	-	372	WP_005598830.1	CrcB family protein	-
DRF63_RS08385	1792701..1793765	-	1065	WP_043991897.1	MFS transporter	-
DRF63_RS08390	1793860..1794969	+	1110	WP_005598834.1	anhydro-N-acetylmuramic acid kinase	-
DRF63_RS08395	1795023..1795937	+	915	WP_005598836.1	N-acetylmuramic acid 6-phosphate etherase	-
DRF63_RS08400	1796004..1796885	-	882	WP_005598838.1	50S ribosomal protein L11 methyltransferase	-
DRF63_RS08405	1796968..1797435	-	468	WP_005598840.1	GNAT family N-acetyltransferase	Toxin
DRF63_RS08410	1797439..1797699	-	261	WP_005619269.1	DUF1778 domain-containing protein	Antitoxin
DRF63_RS08415	1797820..1799280	-	1461	WP_005598844.1	metalloprotease TldD	-
DRF63_RS08420	1799410..1800669	+	1260	WP_005598846.1	tRNA lysidine(34) synthetase TilS	-
DRF63_RS08425	1800696..1800986	-	291	WP_005598848.1	DUF5389 family protein	-
DRF63_RS08430	1800988..1801881	-	894	WP_005598850.1	site-specific tyrosine recombinase XerD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (22-142)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-80)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17206.22 Da
• Isoelectric Point: 8.9312

>T107837 WP_005598840.1 NZ_CP030753:c1797435-1796968 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGIKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Nucleotide

• Length: 468 bp

>T107837 NZ_CP030753:c1797435-1796968 [Actinobacillus pleuropneumoniae]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGATAAAAGCATTGCTTGTTCATGCGTTAAACCCGCAAGCAAAAC
AATTTTATTTAAAGTATGGTTTTTCATGTTCACCCATTGATGAGATGGTATTAATGTTAAAACTCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9796.14 Da
• Isoelectric Point: 4.4883

>AT107837 WP_005619269.1 NZ_CP030753:c1797699-1797439 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Nucleotide

• Length: 261 bp

>AT107837 NZ_CP030753:c1797699-1797439 [Actinobacillus pleuropneumoniae]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG

Structures

Antitoxin

• AlphaFold DB: A3N2I7