107832

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 850236..850757 Replicon chromosome
Accession NZ_CP030715
Organism Staphylococcus pseudintermedius strain VB88

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag DNH96_RS04290 Protein ID WP_014613364.1
Coordinates 850236..850457 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag DNH96_RS04295 Protein ID WP_014613363.1
Coordinates 850470..850757 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DNH96_RS04275 847513..847659 - 147 WP_014613367.1 Lmo0850 family protein -
DNH96_RS04280 (DNH96_04260) 847745..849925 - 2181 WP_037542539.1 heavy metal translocating P-type ATPase -
DNH96_RS04285 (DNH96_04265) 850026..850232 - 207 WP_014613365.1 cation transporter -
DNH96_RS04290 (DNH96_04270) 850236..850457 - 222 WP_014613364.1 heavy metal-associated domain-containing protein Toxin
DNH96_RS04295 (DNH96_04275) 850470..850757 - 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
DNH96_RS04300 (DNH96_04280) 850889..852379 + 1491 WP_014613362.1 cardiolipin synthase -
DNH96_RS04305 (DNH96_04285) 852400..853056 + 657 WP_014613361.1 HD domain-containing protein -
DNH96_RS04310 (DNH96_04290) 853110..853976 - 867 WP_014613360.1 membrane protein insertase YidC -
DNH96_RS04315 (DNH96_04295) 854065..854703 - 639 WP_014613359.1 thiamine phosphate synthase -
DNH96_RS04320 (DNH96_04300) 854693..855496 - 804 WP_014613358.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T107832 WP_014613364.1 NZ_CP030715:c850457-850236 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T107832 NZ_CP030715:c850457-850236 [Staphylococcus pseudintermedius]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT107832 WP_014613363.1 NZ_CP030715:c850757-850470 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT107832 NZ_CP030715:c850757-850470 [Staphylococcus pseudintermedius]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References