Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2414140..2414661 Replicon chromosome
Accession NZ_CP030374
Organism Staphylococcus pseudintermedius strain AH18

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag DNH82_RS11310 Protein ID WP_014613364.1
Coordinates 2414140..2414361 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag DNH82_RS11315 Protein ID WP_014613363.1
Coordinates 2414374..2414661 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DNH82_RS11290 (DNH82_11400) 2409721..2410449 - 729 WP_096533615.1 peptidase -
DNH82_RS11295 2411417..2411563 - 147 WP_014613367.1 Lmo0850 family protein -
DNH82_RS11300 (DNH82_11410) 2411649..2413829 - 2181 WP_096533614.1 heavy metal translocating P-type ATPase -
DNH82_RS11305 (DNH82_11415) 2413930..2414136 - 207 WP_014613365.1 cation transporter -
DNH82_RS11310 (DNH82_11420) 2414140..2414361 - 222 WP_014613364.1 heavy metal-associated domain-containing protein Toxin
DNH82_RS11315 (DNH82_11425) 2414374..2414661 - 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
DNH82_RS11320 (DNH82_11430) 2414793..2416283 + 1491 WP_014613362.1 cardiolipin synthase -
DNH82_RS11325 (DNH82_11435) 2416304..2416960 + 657 WP_014613361.1 HD domain-containing protein -
DNH82_RS12720 2417146..2417316 + 171 WP_247645581.1 hypothetical protein -
DNH82_RS12725 2417667..2418450 + 784 Protein_2205 ISL3 family transposase -
DNH82_RS11335 (DNH82_11445) 2418491..2419357 - 867 WP_014613360.1 membrane protein insertase YidC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T107830 WP_014613364.1 NZ_CP030374:c2414361-2414140 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T107830 NZ_CP030374:c2414361-2414140 [Staphylococcus pseudintermedius]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT107830 WP_014613363.1 NZ_CP030374:c2414661-2414374 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT107830 NZ_CP030374:c2414661-2414374 [Staphylococcus pseudintermedius]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References