Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 1896583..1897133 Replicon chromosome
Accession NZ_CP030352
Organism Novosphingobium sp. P6W

Toxin (Protein)


Gene name parE Uniprot ID A0A2Z5EBC6
Locus tag TQ38_RS09235 Protein ID WP_043980155.1
Coordinates 1896831..1897133 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2Z5EEN0
Locus tag TQ38_RS09230 Protein ID WP_043980176.1
Coordinates 1896583..1896828 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TQ38_RS09205 1892519..1893658 + 1140 WP_043980160.1 DUF1501 domain-containing protein -
TQ38_RS09210 1894052..1894516 + 465 WP_043980159.1 hypothetical protein -
TQ38_RS09215 1894680..1894916 - 237 WP_082057975.1 DUF1214 domain-containing protein -
TQ38_RS09220 1894932..1895936 - 1005 WP_052506015.1 DUF1254 domain-containing protein -
TQ38_RS30560 1895986..1896444 + 459 WP_205316020.1 hypothetical protein -
TQ38_RS09230 1896583..1896828 + 246 WP_043980176.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
TQ38_RS09235 1896831..1897133 + 303 WP_043980155.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TQ38_RS09240 1897350..1897580 + 231 Protein_1818 IS110 family transposase -
TQ38_RS09245 1897773..1898192 + 420 Protein_1819 site-specific integrase -
TQ38_RS09250 1898502..1898831 + 330 WP_043980152.1 metalloregulator ArsR/SmtB family transcription factor -
TQ38_RS09255 1898843..1899268 + 426 WP_043980149.1 arsenate reductase (glutaredoxin) -
TQ38_RS09260 1899309..1900340 + 1032 WP_205316105.1 ACR3 family arsenite efflux transporter -
TQ38_RS09265 1900337..1901089 + 753 WP_043980142.1 arsenical resistance protein ArsH -
TQ38_RS09270 1901423..1901772 - 350 Protein_1824 ParB N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1894932..1906760 11828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(6-64)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11453.89 Da        Isoelectric Point: 4.6847

>T107826 WP_043980155.1 NZ_CP030352:1896831-1897133 [Novosphingobium sp. P6W]
VPRFRLTRAAADDLTTIFLEGIEQFGLPQVDTYHEGLSAIFAFLAEYPQAARLREEISPPVRVHPYKAHLVIYDVGDEDE
VIILRVRHGREDWISSNYDG

Download         Length: 303 bp

>T107826 NZ_CP030352:1896831-1897133 [Novosphingobium sp. P6W]
GTGCCTCGCTTCCGCTTAACGCGCGCCGCAGCCGACGATCTGACAACCATCTTTCTCGAAGGCATCGAGCAGTTCGGACT
ACCTCAAGTCGATACCTATCACGAAGGGCTGAGCGCGATATTCGCGTTTCTTGCCGAGTATCCTCAGGCTGCTCGATTGC
GGGAGGAAATATCGCCTCCTGTCCGCGTGCATCCCTACAAGGCACATCTGGTGATTTATGACGTGGGAGATGAGGACGAG
GTCATCATTCTGCGTGTCCGGCATGGTAGGGAAGATTGGATATCCTCGAACTACGACGGCTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9059.11 Da        Isoelectric Point: 4.7265

>AT107826 WP_043980176.1 NZ_CP030352:1896583-1896828 [Novosphingobium sp. P6W]
VATMNISLPDPMKQWVEAQADTGRYSNASDYVRDLIRRDQERADKVAVMQRFVDEARASGLSDETMADIRTRAISQAGLQ
A

Download         Length: 246 bp

>AT107826 NZ_CP030352:1896583-1896828 [Novosphingobium sp. P6W]
GTGGCCACGATGAACATCTCACTGCCCGATCCGATGAAGCAATGGGTCGAAGCGCAAGCTGACACTGGTCGGTATAGCAA
TGCCAGCGACTATGTGCGCGATCTCATCCGCCGTGACCAAGAACGCGCCGACAAAGTCGCGGTCATGCAGCGCTTTGTCG
ATGAGGCCCGCGCCAGCGGTTTGAGCGACGAGACGATGGCGGACATCCGGACGCGAGCGATCAGCCAGGCTGGCTTGCAA
GCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z5EBC6

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z5EEN0

References