Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | NpoTA/ParE(toxin) |
| Location | 1069807..1070966 | Replicon | chromosome |
| Accession | NZ_CP030352 | ||
| Organism | Novosphingobium sp. P6W | ||
Toxin (Protein)
| Gene name | NpoT | Uniprot ID | A0A2Z5E959 |
| Locus tag | TQ38_RS05180 | Protein ID | WP_043976760.1 |
| Coordinates | 1070670..1070966 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | NpoA | Uniprot ID | A0A2Z5E8M1 |
| Locus tag | TQ38_RS05175 | Protein ID | WP_043976759.1 |
| Coordinates | 1069807..1070658 (+) | Length | 284 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TQ38_RS05155 | 1065172..1066020 | + | 849 | WP_043976756.1 | transglutaminase family protein | - |
| TQ38_RS05165 | 1066194..1066943 | - | 750 | WP_043976758.1 | Crp/Fnr family transcriptional regulator | - |
| TQ38_RS05170 | 1067127..1069355 | + | 2229 | WP_205316075.1 | catalase | - |
| TQ38_RS05175 | 1069807..1070658 | + | 852 | WP_043976759.1 | glucose 1-dehydrogenase | Antitoxin |
| TQ38_RS05180 | 1070670..1070966 | + | 297 | WP_043976760.1 | hypothetical protein | Toxin |
| TQ38_RS05185 | 1070976..1072007 | - | 1032 | WP_043976761.1 | c-type cytochrome | - |
| TQ38_RS05190 | 1072004..1072603 | - | 600 | WP_043976762.1 | cytochrome c oxidase assembly protein | - |
| TQ38_RS05195 | 1072600..1072980 | - | 381 | WP_043976763.1 | membrane protein | - |
| TQ38_RS05200 | 1072977..1075499 | - | 2523 | WP_043976765.1 | cytochrome c oxidase subunit I | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 10580.43 Da Isoelectric Point: 10.8862
>T107825 WP_043976760.1 NZ_CP030352:1070670-1070966 [Novosphingobium sp. P6W]
MPQGDKSSYTDKQKRQAAHIAQGYEDRGVSHDEAEGRAWATVNKESGGGNKSGSGRGKKDSHISSTRGGKAHKSGSPEQR
SAAARKGWDTRRRKQAET
MPQGDKSSYTDKQKRQAAHIAQGYEDRGVSHDEAEGRAWATVNKESGGGNKSGSGRGKKDSHISSTRGGKAHKSGSPEQR
SAAARKGWDTRRRKQAET
Download Length: 297 bp
>T107825 NZ_CP030352:1070670-1070966 [Novosphingobium sp. P6W]
ATGCCTCAAGGCGACAAGAGCAGCTATACCGACAAGCAGAAGCGCCAGGCGGCCCACATAGCGCAGGGCTATGAGGATCG
CGGTGTCAGCCATGACGAGGCCGAAGGGCGGGCCTGGGCCACCGTCAACAAGGAATCGGGCGGCGGCAACAAGTCCGGTT
CCGGCAGGGGGAAGAAGGACAGCCATATTTCTTCCACGCGCGGGGGTAAGGCGCACAAGTCCGGCTCGCCGGAGCAGCGT
TCCGCCGCCGCACGCAAGGGCTGGGATACCCGGCGCAGGAAGCAGGCTGAAACCTGA
ATGCCTCAAGGCGACAAGAGCAGCTATACCGACAAGCAGAAGCGCCAGGCGGCCCACATAGCGCAGGGCTATGAGGATCG
CGGTGTCAGCCATGACGAGGCCGAAGGGCGGGCCTGGGCCACCGTCAACAAGGAATCGGGCGGCGGCAACAAGTCCGGTT
CCGGCAGGGGGAAGAAGGACAGCCATATTTCTTCCACGCGCGGGGGTAAGGCGCACAAGTCCGGCTCGCCGGAGCAGCGT
TCCGCCGCCGCACGCAAGGGCTGGGATACCCGGCGCAGGAAGCAGGCTGAAACCTGA
Antitoxin
Download Length: 284 a.a. Molecular weight: 30330.22 Da Isoelectric Point: 4.7190
>AT107825 WP_043976759.1 NZ_CP030352:1069807-1070658 [Novosphingobium sp. P6W]
MTQTIPMIHEDALPGHESRLEPKPEWQPRYSGSGRLAGKVAIVTGADSGIGRAVAALYAREGADIAIVYLLEDDDAQETI
RIVESEGRRAIAIKADVGSRAACDAIVEQTLTAFGKVDILVNNAGEQHPDKDITDISEEQLKRTFQTNIFAMFYLVQAAR
PHLQAGAAIINCTSVTMYQGSKELLDYSATKGAITAFTRSLSENLIEHGIRVNAVAPGPIWTPLNPCGGASEEKLEHFGE
STPMGRPGQPNEVAPSFLFLACDDASYMSGQVLHPNGGIIVNG
MTQTIPMIHEDALPGHESRLEPKPEWQPRYSGSGRLAGKVAIVTGADSGIGRAVAALYAREGADIAIVYLLEDDDAQETI
RIVESEGRRAIAIKADVGSRAACDAIVEQTLTAFGKVDILVNNAGEQHPDKDITDISEEQLKRTFQTNIFAMFYLVQAAR
PHLQAGAAIINCTSVTMYQGSKELLDYSATKGAITAFTRSLSENLIEHGIRVNAVAPGPIWTPLNPCGGASEEKLEHFGE
STPMGRPGQPNEVAPSFLFLACDDASYMSGQVLHPNGGIIVNG
Download Length: 852 bp
>AT107825 NZ_CP030352:1069807-1070658 [Novosphingobium sp. P6W]
ATGACCCAGACCATCCCCATGATCCATGAAGACGCGCTGCCGGGCCATGAAAGTCGGCTGGAGCCCAAGCCCGAGTGGCA
GCCGCGATATTCTGGCTCAGGACGGCTCGCGGGTAAGGTTGCCATCGTGACAGGTGCGGACAGCGGGATCGGCCGCGCGG
TGGCGGCGCTCTACGCGCGCGAAGGCGCTGATATCGCCATAGTTTATCTGCTGGAAGATGACGATGCCCAGGAGACCATT
CGCATAGTGGAAAGCGAAGGGCGGCGCGCGATCGCCATCAAAGCCGACGTGGGTTCGCGCGCGGCATGCGACGCAATTGT
CGAACAGACGCTGACCGCCTTCGGCAAAGTAGACATCCTGGTTAACAACGCCGGCGAGCAGCACCCCGACAAGGACATCA
CCGACATCTCGGAAGAGCAGTTGAAGCGAACCTTTCAGACCAACATCTTCGCCATGTTCTATCTTGTGCAGGCGGCCCGT
CCGCATCTTCAGGCAGGCGCCGCGATCATCAACTGCACCAGTGTGACCATGTACCAGGGGAGCAAGGAACTGCTCGACTA
CAGCGCCACCAAAGGCGCGATCACAGCATTCACCCGTTCGCTTTCGGAGAACCTGATCGAGCATGGCATTCGGGTAAACG
CAGTGGCGCCGGGGCCGATCTGGACCCCGCTCAACCCCTGCGGCGGCGCGAGCGAAGAAAAGCTGGAGCATTTCGGTGAA
AGCACTCCGATGGGCCGTCCGGGTCAGCCCAATGAAGTCGCGCCTTCGTTTCTGTTCCTGGCCTGCGATGATGCGAGCTA
CATGAGCGGACAGGTTCTGCATCCCAATGGCGGTATCATCGTCAACGGTTGA
ATGACCCAGACCATCCCCATGATCCATGAAGACGCGCTGCCGGGCCATGAAAGTCGGCTGGAGCCCAAGCCCGAGTGGCA
GCCGCGATATTCTGGCTCAGGACGGCTCGCGGGTAAGGTTGCCATCGTGACAGGTGCGGACAGCGGGATCGGCCGCGCGG
TGGCGGCGCTCTACGCGCGCGAAGGCGCTGATATCGCCATAGTTTATCTGCTGGAAGATGACGATGCCCAGGAGACCATT
CGCATAGTGGAAAGCGAAGGGCGGCGCGCGATCGCCATCAAAGCCGACGTGGGTTCGCGCGCGGCATGCGACGCAATTGT
CGAACAGACGCTGACCGCCTTCGGCAAAGTAGACATCCTGGTTAACAACGCCGGCGAGCAGCACCCCGACAAGGACATCA
CCGACATCTCGGAAGAGCAGTTGAAGCGAACCTTTCAGACCAACATCTTCGCCATGTTCTATCTTGTGCAGGCGGCCCGT
CCGCATCTTCAGGCAGGCGCCGCGATCATCAACTGCACCAGTGTGACCATGTACCAGGGGAGCAAGGAACTGCTCGACTA
CAGCGCCACCAAAGGCGCGATCACAGCATTCACCCGTTCGCTTTCGGAGAACCTGATCGAGCATGGCATTCGGGTAAACG
CAGTGGCGCCGGGGCCGATCTGGACCCCGCTCAACCCCTGCGGCGGCGCGAGCGAAGAAAAGCTGGAGCATTTCGGTGAA
AGCACTCCGATGGGCCGTCCGGGTCAGCCCAATGAAGTCGCGCCTTCGTTTCTGTTCCTGGCCTGCGATGATGCGAGCTA
CATGAGCGGACAGGTTCTGCATCCCAATGGCGGTATCATCGTCAACGGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2Z5E959 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2Z5E8M1 |