Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 4503033..4503538 Replicon chromosome
Accession NZ_CP030351
Organism Pseudomonas aeruginosa strain AR_460

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag CSC46_RS21285 Protein ID WP_003121619.1
Coordinates 4503257..4503538 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag CSC46_RS21280 Protein ID WP_003112628.1
Coordinates 4503033..4503260 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC46_RS21255 4498051..4499544 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
CSC46_RS21260 4499713..4501140 + 1428 WP_112208117.1 GABA permease -
CSC46_RS21265 4501222..4501563 - 342 WP_003101229.1 alkylphosphonate utilization protein -
CSC46_RS21270 4501636..4502136 - 501 WP_112208119.1 LEA type 2 family protein -
CSC46_RS21275 4502237..4502857 + 621 WP_003101226.1 hypothetical protein -
CSC46_RS21280 4503033..4503260 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
CSC46_RS21285 4503257..4503538 + 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
CSC46_RS21290 4503838..4504746 + 909 WP_023083551.1 LysR family transcriptional regulator -
CSC46_RS21295 4504778..4505164 - 387 WP_014602345.1 aegerolysin family protein -
CSC46_RS21300 4505368..4506102 - 735 WP_003117208.1 GntR family transcriptional regulator -
CSC46_RS21305 4506203..4506889 - 687 WP_003083762.1 FadR family transcriptional regulator -
CSC46_RS21310 4506938..4508287 - 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T107822 WP_003121619.1 NZ_CP030351:4503257-4503538 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T107822 NZ_CP030351:4503257-4503538 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT107822 WP_003112628.1 NZ_CP030351:4503033-4503260 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT107822 NZ_CP030351:4503033-4503260 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References