Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3469620..3470225 Replicon chromosome
Accession NZ_CP030347
Organism Enterobacter hormaechei strain AR_038

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag CSB67_RS18440 Protein ID WP_012906750.1
Coordinates 3469620..3469799 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A822X3T2
Locus tag CSB67_RS18445 Protein ID WP_032619507.1
Coordinates 3469821..3470225 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB67_RS18415 3464949..3465665 + 717 WP_032619512.1 ABC transporter ATP-binding protein -
CSB67_RS18420 3465831..3466301 + 471 WP_017384432.1 hypothetical protein -
CSB67_RS18425 3466307..3467233 - 927 WP_032619511.1 LysR family transcriptional regulator -
CSB67_RS18430 3467263..3467586 - 324 WP_017384434.1 hypothetical protein -
CSB67_RS18435 3467589..3468344 - 756 Protein_3304 DUF4225 domain-containing protein -
CSB67_RS18440 3469620..3469799 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
CSB67_RS18445 3469821..3470225 + 405 WP_032619507.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CSB67_RS18450 3470266..3471336 - 1071 WP_032635096.1 glycosyltransferase family 9 protein -
CSB67_RS18455 3471413..3471991 - 579 WP_032619505.1 tail fiber assembly protein -
CSB67_RS18460 3471991..3474168 - 2178 WP_050597130.1 phage tail protein -
CSB67_RS18465 3474171..3474722 - 552 WP_032619504.1 phage tail protein I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3466307..3474722 8415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T107816 WP_012906750.1 NZ_CP030347:3469620-3469799 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T107816 NZ_CP030347:3469620-3469799 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTTAAAGGCAGTCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14676.53 Da        Isoelectric Point: 4.2136

>AT107816 WP_032619507.1 NZ_CP030347:3469821-3470225 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGEDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVINQR

Download         Length: 405 bp

>AT107816 NZ_CP030347:3469821-3470225 [Enterobacter hormaechei]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGAAGATTATCAGGACGCGATCGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCCGAAGCAACGACCGTCGAAAACTGGCTATCTGATCCGGAGTACGCCGGTGCGGTATGGGCCCTAGTTGAC
GTGGATATAACACGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTACCCTCATTACTGATCCGACGTATTGATCA
GTTTGTGGCCGCGCATCCTGAATATGGAAGCCGTTCGGGCTTCCTTTCTCGCGTCGCTGCTGACAAGGTTATTAATCAAC
GATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A822X3T2

References