Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2937639..2938378 Replicon chromosome
Accession NZ_CP030347
Organism Enterobacter hormaechei strain AR_038

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag CSB67_RS15815 Protein ID WP_017382345.1
Coordinates 2937893..2938378 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag CSB67_RS15810 Protein ID WP_003857131.1
Coordinates 2937639..2937905 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB67_RS15790 2933115..2934101 + 987 WP_017382341.1 DUF979 domain-containing protein -
CSB67_RS15795 2934111..2935106 + 996 WP_023303746.1 DUF2891 domain-containing protein -
CSB67_RS15800 2935128..2936516 - 1389 WP_032619651.1 MFS transporter -
CSB67_RS15805 2936646..2937575 + 930 WP_023303744.1 LysR family transcriptional regulator -
CSB67_RS15810 2937639..2937905 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
CSB67_RS15815 2937893..2938378 + 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
CSB67_RS15820 2938429..2938998 - 570 WP_017382346.1 hypothetical protein -
CSB67_RS15825 2939362..2939976 - 615 WP_082194854.1 NUDIX hydrolase -
CSB67_RS15830 2939976..2941268 - 1293 WP_032634391.1 glycoside hydrolase -
CSB67_RS15835 2941373..2942131 - 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
CSB67_RS15840 2942218..2942802 + 585 WP_032634393.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T107815 WP_017382345.1 NZ_CP030347:2937893-2938378 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T107815 NZ_CP030347:2937893-2938378 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAGCGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT107815 WP_003857131.1 NZ_CP030347:2937639-2937905 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT107815 NZ_CP030347:2937639-2937905 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References