Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1953445..1954102 Replicon chromosome
Accession NZ_CP030347
Organism Enterobacter hormaechei strain AR_038

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag CSB67_RS10950 Protein ID WP_017382887.1
Coordinates 1953692..1954102 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag CSB67_RS10945 Protein ID WP_003863437.1
Coordinates 1953445..1953711 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB67_RS10920 1949624..1949953 - 330 Protein_1855 MurR/RpiR family transcriptional regulator -
CSB67_RS10925 1949971..1950668 - 698 Protein_1856 IS1 family transposase -
CSB67_RS10930 1950722..1951132 - 411 Protein_1857 MurR/RpiR family transcriptional regulator -
CSB67_RS10935 1951399..1952058 + 660 WP_003863433.1 hemolysin III family protein -
CSB67_RS10940 1952170..1953150 - 981 WP_022649306.1 tRNA-modifying protein YgfZ -
CSB67_RS10945 1953445..1953711 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
CSB67_RS10950 1953692..1954102 + 411 WP_017382887.1 protein YgfX Toxin
CSB67_RS10955 1954104..1954625 - 522 WP_015571793.1 flavodoxin FldB -
CSB67_RS10960 1954727..1955623 + 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
CSB67_RS10965 1955652..1956365 + 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CSB67_RS10970 1956371..1958104 + 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T107807 WP_017382887.1 NZ_CP030347:1953692-1954102 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T107807 NZ_CP030347:1953692-1954102 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT107807 WP_003863437.1 NZ_CP030347:1953445-1953711 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT107807 NZ_CP030347:1953445-1953711 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References