Detailed information of TA system TA107804

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 567641..568252
• Replicon: chromosome
• Accession: NZ_CP030347
• Organism: Enterobacter hormaechei strain AR_038

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: D2TUP9
• Locus tag: CSB67_RS03940
• Protein ID: WP_012906750.1
• Coordinates: 567641..567820 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CSB67_RS03945
• Protein ID: WP_032634114.1
• Coordinates: 567842..568252 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB67_RS03910	563118..563360	-	243	WP_017382623.1	envelope stress response protein PspG	-
CSB67_RS03915	563497..564534	-	1038	WP_050597113.1	tRNA dihydrouridine(20/20a) synthase DusA	-
CSB67_RS03920	564622..565716	+	1095	WP_032634111.1	site-specific integrase	-
CSB67_RS03925	565910..566680	-	771	WP_032634139.1	hypothetical protein	-
CSB67_RS03930	566945..567190	+	246	WP_032634112.1	DinI-like family protein	-
CSB67_RS03935	567174..567440	+	267	WP_133259045.1	hypothetical protein	-
CSB67_RS03940	567641..567820	+	180	WP_012906750.1	type II toxin-antitoxin system HicA family toxin	Toxin
CSB67_RS03945	567842..568252	+	411	WP_032634114.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CSB67_RS03950	568334..568900	+	567	WP_032634115.1	serine acetyltransferase	-
CSB67_RS03955	568904..569326	-	423	WP_032634116.1	tail fiber assembly protein	-
CSB67_RS03960	569328..571559	-	2232	WP_082194851.1	phage tail protein	-
CSB67_RS03965	571562..572113	-	552	WP_032634117.1	phage tail protein I	-
CSB67_RS03970	572106..573020	-	915	WP_032634118.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	560477..612167	51690

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6644.85 Da
• Isoelectric Point: 10.9132

>T107804 WP_012906750.1 NZ_CP030347:567641-567820 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Nucleotide

• Length: 180 bp

>T107804 NZ_CP030347:567641-567820 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTTAAAGGCAGTCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATTA
AAAAACAGGCGGGGCTCTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14920.82 Da
• Isoelectric Point: 4.3170

>AT107804 WP_032634114.1 NZ_CP030347:567842-568252 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYTGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Nucleotide

• Length: 411 bp

>AT107804 NZ_CP030347:567842-568252 [Enterobacter hormaechei]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATTGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCGGAAGCAACGACTGTCGAAAACTGGCTATCTGATCCGGAATACACCGGTGCGGTATGGGCCCTGGTTGAC
GTGGATATAACTCGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTTCCCTCATTACTGATCCGTCGTATCGATCA
GTTTGTGGCCGCGCATCCAGAATACGGCAGTCGGTCTGGCTTCTTATCGCGCGTCGCGGCAGATAAAGTAATTGGACGAG
AAAAACGATAA

Structures

Toxin

• AlphaFold DB: A0A7D6XDK4