Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 129528..130062 Replicon plasmid unnamed1
Accession NZ_CP030345
Organism Enterobacter hormaechei strain AR_038

Toxin (Protein)


Gene name relE Uniprot ID A0A6P1V8P2
Locus tag CSB67_RS00815 Protein ID WP_000143805.1
Coordinates 129772..130062 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A387K2U4
Locus tag CSB67_RS00810 Protein ID WP_032635065.1
Coordinates 129528..129782 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB67_RS00790 124881..125330 - 450 WP_032635063.1 hypothetical protein -
CSB67_RS00795 125580..127409 - 1830 WP_032635064.1 hypothetical protein -
CSB67_RS00800 128177..128572 + 396 WP_032635081.1 hypothetical protein -
CSB67_RS00805 128659..129369 + 711 WP_025760373.1 tyrosine-type recombinase/integrase -
CSB67_RS00810 129528..129782 + 255 WP_032635065.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CSB67_RS00815 129772..130062 + 291 WP_000143805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSB67_RS00825 130235..130939 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
CSB67_RS00830 131005..131757 + 753 Protein_149 replication initiation protein RepM -
CSB67_RS00835 131824..132366 + 543 WP_004896925.1 plasmid replication DNA-binding protein -
CSB67_RS00840 132725..133608 - 884 Protein_151 Mph(E) family macrolide 2'-phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / armA / sul1 / qacE / blaNDM-1 / aadA2 / dfrA12 / aac(3)-IId / blaTEM-1B / blaCTX-M-15 / blaOXA-1 / aac(6')-Ib-cr / aac(6')-Ib / ant(3'')-Ia / blaOXA-9 - 1..152715 152715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-47)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11463.41 Da        Isoelectric Point: 10.2689

>T107803 WP_000143805.1 NZ_CP030345:129772-130062 [Enterobacter hormaechei]
MTFNVEFDERAFKEWNKLEKTIREQFKKKLKKLQQNPYVESARLHGDLAGCFKIKLRASGFRLIYKVIDDEIVIWVVAVG
KREDEKAYETARKRLL

Download         Length: 291 bp

>T107803 NZ_CP030345:129772-130062 [Enterobacter hormaechei]
ATGACCTTTAATGTTGAATTTGACGAAAGGGCGTTTAAGGAATGGAATAAGCTCGAAAAGACGATCCGTGAGCAATTCAA
AAAGAAGCTAAAAAAGCTTCAGCAAAACCCTTATGTGGAATCAGCCCGACTGCATGGTGATCTGGCTGGCTGCTTTAAAA
TAAAGCTGAGAGCATCTGGTTTTCGTTTGATTTACAAGGTTATCGATGACGAGATTGTTATATGGGTGGTCGCAGTAGGT
AAACGGGAAGACGAAAAAGCCTATGAAACGGCCCGAAAGCGTCTTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9722.07 Da        Isoelectric Point: 4.4356

>AT107803 WP_032635065.1 NZ_CP030345:129528-129782 [Enterobacter hormaechei]
MSTIQIRVDDELKKEAYQAFEKLNLSPSDALRLFLRYVAENEKLPFAEVSVMVSEDDEDADILAVVRERLKNPARRIRVN
VDDL

Download         Length: 255 bp

>AT107803 NZ_CP030345:129528-129782 [Enterobacter hormaechei]
ATGAGCACAATTCAGATTCGCGTTGATGACGAGCTGAAAAAAGAGGCCTATCAGGCCTTTGAAAAACTGAATCTGTCGCC
TTCAGACGCACTTCGTCTGTTCCTGCGATATGTTGCAGAGAACGAAAAACTCCCCTTTGCTGAAGTCTCAGTGATGGTGA
GCGAAGATGATGAAGACGCTGATATTCTGGCAGTGGTTCGGGAAAGACTGAAAAATCCTGCAAGACGGATCAGGGTTAAC
GTTGATGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1V8P2

Antitoxin

Source ID Structure
AlphaFold DB A0A387K2U4

References