Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 7612..8146 Replicon plasmid unnamed1
Accession NZ_CP030345
Organism Enterobacter hormaechei strain AR_038

Toxin (Protein)


Gene name relE Uniprot ID A0A6P1V8P2
Locus tag CSB67_RS00045 Protein ID WP_000143805.1
Coordinates 7856..8146 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A387K2U4
Locus tag CSB67_RS00040 Protein ID WP_032635065.1
Coordinates 7612..7866 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB67_RS00025 4453..5493 - 1041 WP_111978105.1 hypothetical protein -
CSB67_RS00030 6261..6656 + 396 WP_032635081.1 hypothetical protein -
CSB67_RS00035 6743..7453 + 711 WP_025760373.1 tyrosine-type recombinase/integrase -
CSB67_RS00040 7612..7866 + 255 WP_032635065.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CSB67_RS00045 7856..8146 + 291 WP_000143805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSB67_RS00055 8319..9023 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
CSB67_RS00060 9089..9841 + 753 Protein_10 replication initiation protein RepM -
CSB67_RS00065 9908..10450 + 543 WP_004896925.1 plasmid replication DNA-binding protein -
CSB67_RS00070 10809..11693 - 885 WP_000155092.1 Mph(E) family macrolide 2'-phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / armA / sul1 / qacE / blaNDM-1 / aadA2 / dfrA12 / aac(3)-IId / blaTEM-1B / blaCTX-M-15 / blaOXA-1 / aac(6')-Ib-cr / aac(6')-Ib / ant(3'')-Ia / blaOXA-9 - 1..152715 152715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-47)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11463.41 Da        Isoelectric Point: 10.2689

>T107801 WP_000143805.1 NZ_CP030345:7856-8146 [Enterobacter hormaechei]
MTFNVEFDERAFKEWNKLEKTIREQFKKKLKKLQQNPYVESARLHGDLAGCFKIKLRASGFRLIYKVIDDEIVIWVVAVG
KREDEKAYETARKRLL

Download         Length: 291 bp

>T107801 NZ_CP030345:7856-8146 [Enterobacter hormaechei]
ATGACCTTTAATGTTGAATTTGACGAAAGGGCGTTTAAGGAATGGAATAAGCTCGAAAAGACGATCCGTGAGCAATTCAA
AAAGAAGCTAAAAAAGCTTCAGCAAAACCCTTATGTGGAATCAGCCCGACTGCATGGTGATCTGGCTGGCTGCTTTAAAA
TAAAGCTGAGAGCATCTGGTTTTCGTTTGATTTACAAGGTTATCGATGACGAGATTGTTATATGGGTGGTCGCAGTAGGT
AAACGGGAAGACGAAAAAGCCTATGAAACGGCCCGAAAGCGTCTTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9722.07 Da        Isoelectric Point: 4.4356

>AT107801 WP_032635065.1 NZ_CP030345:7612-7866 [Enterobacter hormaechei]
MSTIQIRVDDELKKEAYQAFEKLNLSPSDALRLFLRYVAENEKLPFAEVSVMVSEDDEDADILAVVRERLKNPARRIRVN
VDDL

Download         Length: 255 bp

>AT107801 NZ_CP030345:7612-7866 [Enterobacter hormaechei]
ATGAGCACAATTCAGATTCGCGTTGATGACGAGCTGAAAAAAGAGGCCTATCAGGCCTTTGAAAAACTGAATCTGTCGCC
TTCAGACGCACTTCGTCTGTTCCTGCGATATGTTGCAGAGAACGAAAAACTCCCCTTTGCTGAAGTCTCAGTGATGGTGA
GCGAAGATGATGAAGACGCTGATATTCTGGCAGTGGTTCGGGAAAGACTGAAAAATCCTGCAAGACGGATCAGGGTTAAC
GTTGATGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1V8P2

Antitoxin

Source ID Structure
AlphaFold DB A0A387K2U4

References