Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5109974..5110490 Replicon chromosome
Accession NZ_CP030341
Organism Klebsiella pneumoniae strain AR_362

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag CSB99_RS25985 Protein ID WP_002886902.1
Coordinates 5109974..5110258 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CSB99_RS25990 Protein ID WP_002886901.1
Coordinates 5110248..5110490 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB99_RS25965 5105458..5105766 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
CSB99_RS30455 5105851..5106024 + 174 WP_002886906.1 hypothetical protein -
CSB99_RS25970 5106027..5106770 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CSB99_RS25975 5107127..5109265 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
CSB99_RS25980 5109506..5109970 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CSB99_RS25985 5109974..5110258 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSB99_RS25990 5110248..5110490 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CSB99_RS25995 5110568..5112478 - 1911 WP_004152270.1 BglG family transcription antiterminator -
CSB99_RS26000 5112501..5113655 - 1155 WP_002886900.1 lactonase family protein -
CSB99_RS26005 5113721..5114461 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T107797 WP_002886902.1 NZ_CP030341:c5110258-5109974 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T107797 NZ_CP030341:c5110258-5109974 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT107797 WP_002886901.1 NZ_CP030341:c5110490-5110248 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT107797 NZ_CP030341:c5110490-5110248 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References