Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1163522..1164179 Replicon chromosome
Accession NZ_CP030341
Organism Klebsiella pneumoniae strain AR_362

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CSB99_RS06025 Protein ID WP_002916310.1
Coordinates 1163769..1164179 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CSB99_RS06020 Protein ID WP_002916312.1
Coordinates 1163522..1163788 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB99_RS05995 1158678..1160111 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
CSB99_RS06000 1160230..1160958 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CSB99_RS06005 1161008..1161319 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
CSB99_RS06010 1161483..1162142 + 660 WP_002916317.1 hemolysin III family protein -
CSB99_RS06015 1162293..1163276 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
CSB99_RS06020 1163522..1163788 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CSB99_RS06025 1163769..1164179 + 411 WP_002916310.1 protein YgfX Toxin
CSB99_RS06030 1164186..1164707 - 522 WP_002916308.1 flavodoxin FldB -
CSB99_RS06035 1164808..1165704 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CSB99_RS06040 1165727..1166440 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CSB99_RS06045 1166446..1168179 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T107785 WP_002916310.1 NZ_CP030341:1163769-1164179 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T107785 NZ_CP030341:1163769-1164179 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT107785 WP_002916312.1 NZ_CP030341:1163522-1163788 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT107785 NZ_CP030341:1163522-1163788 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References