Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2972812..2973646 Replicon chromosome
Accession NZ_CP030337
Organism Escherichia coli strain AR_451

Toxin (Protein)


Gene name yeeV Uniprot ID S1PLF5
Locus tag CSC38_RS16255 Protein ID WP_000854690.1
Coordinates 2973269..2973646 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P7N8
Locus tag CSC38_RS16250 Protein ID WP_001305076.1
Coordinates 2972812..2973180 (+) Length 123 a.a.

Genomic Context


CSC38_RS16205CSC38_RS16210CSC38_RS16215CSC38_RS16225CSC38_RS16230CSC38_RS16235CSC38_RS16240CSC38_RS16245CSC38_RS16250CSC38_RS16255CSC38_RS16260CSC38_RS16265CSC38_RS16270CSC38_RS16275CSC38_RS16280CSC38_RS27200
Location: 2967894..2969021 (1128 bp)
Type: Others
Protein ID: Protein_2846
Location: 2969097..2969552 (456 bp)
Type: Others
Protein ID: WP_000581502.1
Location: 2969631..2969864 (234 bp)
Type: Others
Protein ID: WP_000902034.1
Location: 2969965..2970783 (819 bp)
Type: Others
Protein ID: WP_001234620.1
Location: 2970838..2971323 (486 bp)
Type: Others
Protein ID: WP_000849565.1
Location: 2971339..2971815 (477 bp)
Type: Others
Protein ID: WP_001186726.1
Location: 2971878..2972099 (222 bp)
Type: Others
Protein ID: WP_000692329.1
Location: 2972118..2972762 (645 bp)
Type: Others
Protein ID: WP_000094916.1
Location: 2972812..2973180 (369 bp)
Type: Antitoxin
Protein ID: WP_001305076.1
Location: 2973269..2973646 (378 bp)
Type: Toxin
Protein ID: WP_000854690.1
Location: 2973643..2974131 (489 bp)
Type: Others
Protein ID: WP_000761699.1
Location: 2974148..2974345 (198 bp)
Type: Others
Protein ID: WP_000839293.1
Location: 2974430..2975275 (846 bp)
Type: Others
Protein ID: WP_001529401.1
Location: 2975344..2975739 (396 bp)
Type: Others
Protein ID: WP_000208384.1
Location: 2975732..2976665 (934 bp)
Type: Others
Protein ID: Protein_2860
Location: 2977097..2977252 (156 bp)
Type: Others
Protein ID: WP_000729638.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSC38_RS162052967894..2969021+1128Protein_2846hypothetical protein-
CSC38_RS162102969097..2969552+456WP_000581502.1hypothetical protein-
CSC38_RS162152969631..2969864+234WP_000902034.1DUF905 family protein-
CSC38_RS162252969965..2970783+819WP_001234620.1DUF945 domain-containing protein-
CSC38_RS162302970838..2971323+486WP_000849565.1antirestriction protein-
CSC38_RS162352971339..2971815+477WP_001186726.1RadC family protein-
CSC38_RS162402971878..2972099+222WP_000692329.1DUF987 domain-containing protein-
CSC38_RS162452972118..2972762+645WP_000094916.1hypothetical protein-
CSC38_RS162502972812..2973180+369WP_001305076.1type IV toxin-antitoxin system YeeU family antitoxinAntitoxin
CSC38_RS162552973269..2973646+378WP_000854690.1TA system toxin CbtA family proteinToxin
CSC38_RS162602973643..2974131+489WP_000761699.1hypothetical protein-
CSC38_RS162652974148..2974345+198WP_000839293.1DUF957 domain-containing protein-
CSC38_RS162702974430..2975275+846WP_001529401.1DUF4942 domain-containing protein-
CSC38_RS162752975344..2975739+396WP_000208384.1type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein-
CSC38_RS162802975732..2976665+934Protein_2860nucleotidyl transferase AbiEii/AbiGii toxin family protein-
CSC38_RS272002977097..2977252+156WP_000729638.1hypothetical protein-

Associated MGEs


Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island-kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / ugd / kpsT2928535..299485566320
-flankIS/Tn--2977097..2977252155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14057.04 Da        Isoelectric Point: 9.1510

>T107761 WP_000854690.1 NZ_CP030337:2973269-2973646 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T107761 NZ_CP030337:2973269-2973646 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13560.39 Da        Isoelectric Point: 4.7830

>AT107761 WP_001305076.1 NZ_CP030337:2972812-2973180 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT107761 NZ_CP030337:2972812-2973180 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBS1PLF5


Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBS1P7N8

References