Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1882240..1883071 Replicon chromosome
Accession NZ_CP030337
Organism Escherichia coli strain AR_451

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag CSC38_RS10890 Protein ID WP_000854815.1
Coordinates 1882697..1883071 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag CSC38_RS10885 Protein ID WP_001280918.1
Coordinates 1882240..1882608 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC38_RS10830 1877329..1878075 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
CSC38_RS10840 1878158..1878508 + 351 Protein_1863 hypothetical protein -
CSC38_RS10845 1878524..1878934 + 411 WP_000846703.1 hypothetical protein -
CSC38_RS10855 1879155..1879973 + 819 WP_001542275.1 DUF945 domain-containing protein -
CSC38_RS10860 1879973..1880218 + 246 WP_001164966.1 hypothetical protein -
CSC38_RS10865 1880312..1880785 + 474 WP_001542276.1 antirestriction protein -
CSC38_RS10870 1880801..1881277 + 477 WP_001186200.1 RadC family protein -
CSC38_RS10875 1881340..1881561 + 222 WP_000692345.1 DUF987 domain-containing protein -
CSC38_RS10880 1881580..1882224 + 645 WP_000086752.1 hypothetical protein -
CSC38_RS10885 1882240..1882608 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CSC38_RS10890 1882697..1883071 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
CSC38_RS10895 1883068..1883262 + 195 WP_000988600.1 hypothetical protein -
CSC38_RS10900 1883275..1883388 + 114 WP_001161660.1 DUF957 domain-containing protein -
CSC38_RS10905 1883677..1883850 - 174 WP_032082634.1 transposase domain-containing protein -
CSC38_RS10910 1883877..1884059 + 183 WP_001296208.1 hypothetical protein -
CSC38_RS10915 1884160..1884489 - 330 WP_000450409.1 DUF496 family protein -
CSC38_RS10920 1884661..1885719 - 1059 WP_001200889.1 FUSC family protein -
CSC38_RS10925 1885917..1886390 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
CSC38_RS10930 1886509..1887675 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T107758 WP_000854815.1 NZ_CP030337:1882697-1883071 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T107758 NZ_CP030337:1882697-1883071 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT107758 WP_001280918.1 NZ_CP030337:1882240-1882608 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT107758 NZ_CP030337:1882240-1882608 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References