Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3452677..3453295 Replicon chromosome
Accession NZ_CP030331
Organism Escherichia coli strain AR_452

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CSC39_RS18645 Protein ID WP_001291435.1
Coordinates 3453077..3453295 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E9TLB8
Locus tag CSC39_RS18640 Protein ID WP_000344794.1
Coordinates 3452677..3453051 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC39_RS18630 3447766..3448959 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CSC39_RS18635 3448982..3452131 + 3150 WP_001132470.1 multidrug efflux RND transporter permease subunit -
CSC39_RS18640 3452677..3453051 + 375 WP_000344794.1 Hha toxicity modulator TomB Antitoxin
CSC39_RS18645 3453077..3453295 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
CSC39_RS18650 3453466..3454017 + 552 WP_000102564.1 maltose O-acetyltransferase -
CSC39_RS18655 3454133..3454603 + 471 WP_000136192.1 YlaC family protein -
CSC39_RS18660 3454767..3456317 + 1551 WP_001364591.1 cyclic-guanylate-specific phosphodiesterase PdeB -
CSC39_RS18665 3456359..3456712 - 354 WP_000878140.1 DUF1428 domain-containing protein -
CSC39_RS18675 3457091..3457402 + 312 WP_000409911.1 MGMT family protein -
CSC39_RS18680 3457433..3458005 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T107736 WP_001291435.1 NZ_CP030331:3453077-3453295 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T107736 NZ_CP030331:3453077-3453295 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14527.36 Da        Isoelectric Point: 4.9284

>AT107736 WP_000344794.1 NZ_CP030331:3452677-3453051 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGRVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT107736 NZ_CP030331:3452677-3453051 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCCGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References