Detailed information of TA system TA107708

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 2892352..2892857
• Replicon: chromosome
• Accession: NZ_CP030327
• Organism: Pseudomonas aeruginosa strain AR_458

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: CSC44_RS13910
• Protein ID: WP_003083773.1
• Coordinates: 2892576..2892857 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9I707
• Locus tag: CSC44_RS13905
• Protein ID: WP_003112628.1
• Coordinates: 2892352..2892579 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC44_RS13880	2887364..2888857	+	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
CSC44_RS13885	2889026..2890453	+	1428	WP_003083784.1	GABA permease	-
CSC44_RS13890	2890535..2890876	-	342	WP_003101229.1	alkylphosphonate utilization protein	-
CSC44_RS13895	2890949..2891449	-	501	WP_003112629.1	LEA type 2 family protein	-
CSC44_RS13900	2891557..2892177	+	621	WP_112292556.1	hypothetical protein	-
CSC44_RS13905	2892352..2892579	+	228	WP_003112628.1	CopG family ribbon-helix-helix protein	Antitoxin
CSC44_RS13910	2892576..2892857	+	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
CSC44_RS13915	2893157..2894065	+	909	WP_003083769.1	LysR family transcriptional regulator	-
CSC44_RS13920	2894097..2894483	-	387	WP_014602345.1	aegerolysin family protein	-
CSC44_RS13925	2894687..2895421	-	735	WP_003117208.1	GntR family transcriptional regulator	-
CSC44_RS13930	2895522..2896208	-	687	WP_004351997.1	FadR family transcriptional regulator	-
CSC44_RS13935	2896257..2897606	-	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T107708 WP_003083773.1 NZ_CP030327:2892576-2892857 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T107708 NZ_CP030327:2892576-2892857 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGAAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8568.64 Da
• Isoelectric Point: 5.5740

>AT107708 WP_003112628.1 NZ_CP030327:2892352-2892579 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT107708 NZ_CP030327:2892352-2892579 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAAAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: Q9I707