Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1078472..1079260 Replicon chromosome
Accession NZ_CP030326
Organism Staphylococcus aureus strain AR_474

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag CSC59_RS05775 Protein ID WP_000525004.1
Coordinates 1078472..1078933 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag CSC59_RS05780 Protein ID WP_000333630.1
Coordinates 1078946..1079260 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC59_RS05750 1074460..1075263 + 804 WP_000928413.1 TerC family protein -
CSC59_RS05755 1075552..1076757 - 1206 WP_000264741.1 site-specific integrase -
CSC59_RS05760 1076883..1077497 + 615 WP_000191459.1 hypothetical protein -
CSC59_RS05765 1077494..1077640 - 147 WP_001013104.1 hypothetical protein -
CSC59_RS05770 1077870..1078454 - 585 WP_000825948.1 hypothetical protein -
CSC59_RS05775 1078472..1078933 - 462 WP_000525004.1 hypothetical protein Toxin
CSC59_RS05780 1078946..1079260 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
CSC59_RS05785 1079412..1079648 + 237 WP_001121027.1 helix-turn-helix domain-containing protein -
CSC59_RS05790 1079662..1080438 + 777 WP_001148544.1 Rha family transcriptional regulator -
CSC59_RS05795 1080467..1080610 + 144 WP_000939498.1 hypothetical protein -
CSC59_RS05800 1080600..1080809 - 210 WP_000642492.1 hypothetical protein -
CSC59_RS05805 1080865..1081110 + 246 WP_001025401.1 DUF2829 domain-containing protein -
CSC59_RS05810 1081079..1081444 - 366 WP_001128433.1 hypothetical protein -
CSC59_RS05815 1081499..1081714 + 216 WP_001097552.1 hypothetical protein -
CSC59_RS05820 1081739..1082002 + 264 WP_001124160.1 helix-turn-helix domain-containing protein -
CSC59_RS05825 1082015..1082176 + 162 WP_001285954.1 DUF1270 domain-containing protein -
CSC59_RS05830 1082255..1082578 + 324 WP_000175002.1 hypothetical protein -
CSC59_RS05835 1082593..1082955 + 363 WP_000985976.1 hypothetical protein -
CSC59_RS05840 1082952..1084118 + 1167 WP_000762547.1 DUF2800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1075552..1120425 44873


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T107689 WP_000525004.1 NZ_CP030326:c1078933-1078472 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T107689 NZ_CP030326:c1078933-1078472 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT107689 WP_000333630.1 NZ_CP030326:c1079260-1078946 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT107689 NZ_CP030326:c1079260-1078946 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References