Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 899705..900182 Replicon chromosome
Accession NZ_CP030326
Organism Staphylococcus aureus strain AR_474

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC59_RS04725 Protein ID WP_000052076.1
Coordinates 899705..899893 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC59_RS04730 Protein ID WP_001059690.1
Coordinates 899922..900182 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC59_RS04695 895699..896220 + 522 WP_000824482.1 hypothetical protein -
CSC59_RS04700 896561..897247 + 687 WP_000141557.1 thermonuclease family protein -
CSC59_RS04705 897604..897804 + 201 WP_001059082.1 cold-shock protein -
CSC59_RS04710 898296..898514 - 219 WP_000005886.1 hypothetical protein -
CSC59_RS04715 898591..898860 - 270 WP_001004398.1 hypothetical protein -
CSC59_RS04720 898948..899517 - 570 WP_001106658.1 hypothetical protein -
CSC59_RS04725 899705..899893 - 189 WP_000052076.1 hypothetical protein Toxin
CSC59_RS04730 899922..900182 - 261 WP_001059690.1 hypothetical protein Antitoxin
CSC59_RS04735 900523..900726 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSC59_RS04740 900723..900959 - 237 WP_000349581.1 hypothetical protein -
CSC59_RS04745 901184..901765 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSC59_RS04750 901838..902455 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CSC59_RS04755 902610..903104 - 495 WP_000569883.1 GNAT family N-acetyltransferase -
CSC59_RS04760 903503..903925 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSC59_RS04765 904073..904789 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T107688 WP_000052076.1 NZ_CP030326:c899893-899705 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T107688 NZ_CP030326:c899893-899705 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT107688 WP_001059690.1 NZ_CP030326:c900182-899922 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT107688 NZ_CP030326:c900182-899922 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References