Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2440830..2441307 Replicon chromosome
Accession NZ_CP030323
Organism Staphylococcus aureus strain AR_475

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC60_RS12480 Protein ID WP_000052076.1
Coordinates 2441119..2441307 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC60_RS12475 Protein ID WP_001059690.1
Coordinates 2440830..2441090 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC60_RS12440 2436223..2436939 - 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -
CSC60_RS12445 2437087..2437509 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
CSC60_RS12450 2437908..2438402 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
CSC60_RS12455 2438558..2439175 + 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
CSC60_RS12460 2439248..2439829 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
CSC60_RS12465 2440053..2440289 + 237 WP_000368687.1 hypothetical protein -
CSC60_RS12470 2440286..2440489 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSC60_RS12475 2440830..2441090 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSC60_RS12480 2441119..2441307 + 189 WP_000052076.1 hypothetical protein Toxin
CSC60_RS12485 2441495..2442064 + 570 WP_001106657.1 hypothetical protein -
CSC60_RS12490 2442152..2442436 + 285 WP_001004397.1 hypothetical protein -
CSC60_RS12495 2442498..2442716 + 219 WP_000005888.1 hypothetical protein -
CSC60_RS12505 2443215..2443415 - 201 WP_001059082.1 cold-shock protein -
CSC60_RS12510 2443772..2444458 - 687 WP_001823812.1 thermonuclease family protein -
CSC60_RS12515 2444799..2445269 - 471 WP_000824462.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - seb / selq / selk 2411360..2446627 35267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T107686 WP_000052076.1 NZ_CP030323:2441119-2441307 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T107686 NZ_CP030323:2441119-2441307 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT107686 WP_001059690.1 NZ_CP030323:2440830-2441090 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT107686 NZ_CP030323:2440830-2441090 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References