Detailed information of TA system TA107678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1175096..1175610
• Replicon: chromosome
• Accession: NZ_CP030323
• Organism: Staphylococcus aureus strain AR_475

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: CSC60_RS05880
• Protein ID: WP_112380510.1
• Coordinates: 1175401..1175610 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A0D1GBN9
• Locus tag: CSC60_RS05875
• Protein ID: WP_000138934.1
• Coordinates: 1175096..1175389 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC60_RS05835	1170357..1170998	+	642	WP_000483147.1	thiamine phosphate synthase	-
CSC60_RS05840	1171084..1171956	+	873	WP_000725802.1	membrane protein insertase YidC	-
CSC60_RS05865	1172771..1173418	-	648	WP_001187610.1	HD domain-containing protein	-
CSC60_RS05870	1173446..1174930	-	1485	WP_000571549.1	cardiolipin synthase	-
CSC60_RS05875	1175096..1175389	+	294	WP_000138934.1	copper-sensing transcriptional repressor CsoR	Antitoxin
CSC60_RS05880	1175401..1175610	+	210	WP_112380510.1	heavy-metal-associated domain-containing protein	Toxin
CSC60_RS05885	1175738..1175875	+	138	WP_000828354.1	hypothetical protein	-
CSC60_RS05890	1176139..1177341	-	1203	WP_001109939.1	rod shape-determining protein RodA	-
CSC60_RS05895	1177659..1178729	+	1071	WP_000159641.1	D-alanine--D-alanine ligase	-
CSC60_RS05900	1178744..1180102	+	1359	WP_000611468.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7825.74 Da
• Isoelectric Point: 4.1008

>T107678 WP_112380510.1 NZ_CP030323:1175401-1175610 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNIIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T107678 NZ_CP030323:1175401-1175610 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATAATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCATATGAAACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11185.77 Da
• Isoelectric Point: 6.2243

>AT107678 WP_000138934.1 NZ_CP030323:1175096-1175389 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT107678 NZ_CP030323:1175096-1175389 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A0D1GBN9