Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 199506..200245 | Replicon | chromosome |
Accession | NZ_CP030320 | ||
Organism | Klebsiella pneumoniae strain 23 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | - |
Locus tag | DRA87_RS00975 | Protein ID | WP_021312536.1 |
Coordinates | 199760..200245 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | L7SZ29 |
Locus tag | DRA87_RS00970 | Protein ID | WP_003026799.1 |
Coordinates | 199506..199772 (+) | Length | 89 a.a. |
Genomic Context
Location: 195009..197078 (2070 bp)
Type: Others
Protein ID: WP_002922127.1
Type: Others
Protein ID: WP_002922127.1
Location: 197375..198744 (1370 bp)
Type: Others
Protein ID: WP_087830479.1
Type: Others
Protein ID: WP_087830479.1
Location: 198945..199373 (429 bp)
Type: Others
Protein ID: WP_004901287.1
Type: Others
Protein ID: WP_004901287.1
Location: 199506..199772 (267 bp)
Type: Antitoxin
Protein ID: WP_003026799.1
Type: Antitoxin
Protein ID: WP_003026799.1
Location: 199760..200245 (486 bp)
Type: Toxin
Protein ID: WP_021312536.1
Type: Toxin
Protein ID: WP_021312536.1
Location: 200589..200741 (153 bp)
Type: Others
Protein ID: WP_002922102.1
Type: Others
Protein ID: WP_002922102.1
Location: 201043..202662 (1620 bp)
Type: Others
Protein ID: WP_032415799.1
Type: Others
Protein ID: WP_032415799.1
Location: 202761..202973 (213 bp)
Type: Others
Protein ID: WP_000014594.1
Type: Others
Protein ID: WP_000014594.1
Location: 203226..203516 (291 bp)
Type: Others
Protein ID: WP_002921931.1
Type: Others
Protein ID: WP_002921931.1
Location: 203762..205117 (1356 bp)
Type: Others
Protein ID: WP_032415797.1
Type: Others
Protein ID: WP_032415797.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DRA87_RS00955 (DRA87_00965) | 195009..197078 | + | 2070 | WP_002922127.1 | glycine--tRNA ligase subunit beta | - |
DRA87_RS00960 (DRA87_00970) | 197375..198744 | + | 1370 | WP_087830479.1 | IS3 family transposase | - |
DRA87_RS00965 (DRA87_00975) | 198945..199373 | + | 429 | WP_004901287.1 | GFA family protein | - |
DRA87_RS00970 (DRA87_00980) | 199506..199772 | + | 267 | WP_003026799.1 | DUF1778 domain-containing protein | Antitoxin |
DRA87_RS00975 (DRA87_00985) | 199760..200245 | + | 486 | WP_021312536.1 | GNAT family N-acetyltransferase | Toxin |
DRA87_RS00980 (DRA87_00990) | 200589..200741 | + | 153 | WP_002922102.1 | type I toxin-antitoxin system toxin HokA | - |
DRA87_RS00985 (DRA87_00995) | 201043..202662 | + | 1620 | WP_032415799.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
DRA87_RS00990 (DRA87_01000) | 202761..202973 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
DRA87_RS00995 (DRA87_01005) | 203226..203516 | - | 291 | WP_002921931.1 | HTH-type transcriptional regulator | - |
DRA87_RS01000 (DRA87_01010) | 203762..205117 | - | 1356 | WP_032415797.1 | aromatic acid/H+ symport family MFS transporter | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 198019..198744 | 725 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17608.39 Da Isoelectric Point: 10.3370
>T107650 WP_021312536.1 NZ_CP030320:199760-200245 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q
Download Length: 486 bp
>T107650 NZ_CP030320:199760-200245 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10147.59 Da Isoelectric Point: 4.5256
>AT107650 WP_003026799.1 NZ_CP030320:199506-199772 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
Download Length: 267 bp
>AT107650 NZ_CP030320:199506-199772 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
No matching records found |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Q8YL66 |