Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1454368..1455011 Replicon chromosome
Accession NZ_CP030315
Organism Klebsiella pneumoniae strain 11305

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag DRB03_RS07170 Protein ID WP_032433387.1
Coordinates 1454595..1455011 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag DRB03_RS07165 Protein ID WP_001261276.1
Coordinates 1454368..1454598 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRB03_RS07150 (1449390) 1449390..1450477 + 1088 Protein_1396 transcriptional regulator -
DRB03_RS07155 (1450480) 1450480..1452720 + 2241 WP_045326788.1 P-loop NTPase fold protein -
DRB03_RS07160 (1453248) 1453248..1454063 - 816 WP_032433388.1 hypothetical protein -
DRB03_RS07165 (1454368) 1454368..1454598 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DRB03_RS07170 (1454595) 1454595..1455011 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
DRB03_RS07175 (1455167) 1455167..1456147 + 981 WP_032433385.1 hypothetical protein -
DRB03_RS07180 (1456342) 1456342..1457913 - 1572 WP_032433383.1 AAA family ATPase -
DRB03_RS07185 (1458232) 1458232..1458480 + 249 WP_032433382.1 hypothetical protein -
DRB03_RS07190 (1458539) 1458539..1459057 + 519 WP_045326794.1 hypothetical protein -
DRB03_RS07195 (1459088) 1459088..1459579 + 492 WP_032433378.1 hypothetical protein -
DRB03_RS07200 (1459639) 1459639..1459842 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1441282..1482738 41456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T107634 WP_032433387.1 NZ_CP030315:1454595-1455011 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T107634 NZ_CP030315:1454595-1455011 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT107634 WP_001261276.1 NZ_CP030315:1454368-1454598 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT107634 NZ_CP030315:1454368-1454598 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References