Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 167998..168734 Replicon plasmid p11311-1
Accession NZ_CP030314
Organism Klebsiella pneumoniae strain 11311

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag DRA79_RS26200 Protein ID WP_004098919.1
Coordinates 168252..168734 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7D3T1D0
Locus tag DRA79_RS26195 Protein ID WP_004213599.1
Coordinates 167998..168264 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRA79_RS26170 (DRA79_27045) 163230..163787 + 558 WP_004213590.1 recombinase family protein -
DRA79_RS26175 (DRA79_27050) 163790..166759 + 2970 WP_094936121.1 Tn3 family transposase -
DRA79_RS26180 (DRA79_27055) 166801..167295 + 495 WP_004213594.1 hypothetical protein -
DRA79_RS26185 (DRA79_27060) 167356..167559 + 204 WP_004213596.1 HHA domain-containing protein -
DRA79_RS26190 (DRA79_27065) 167573..167803 + 231 WP_004213598.1 hypothetical protein -
DRA79_RS26195 (DRA79_27070) 167998..168264 + 267 WP_004213599.1 DUF1778 domain-containing protein Antitoxin
DRA79_RS26200 (DRA79_27075) 168252..168734 + 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
DRA79_RS26205 (DRA79_27080) 169155..170382 + 1228 Protein_171 IS3 family transposase -
DRA79_RS26210 (DRA79_27085) 170378..170773 - 396 Protein_172 IS3 family transposase -
DRA79_RS26215 (DRA79_27095) 170948..171970 - 1023 WP_004214536.1 porphobilinogen synthase -
DRA79_RS26220 (DRA79_27100) 172034..173380 - 1347 WP_011154555.1 dihydroorotase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA / pla 1..203044 203044
- inside IScluster/Tn - - 163230..170382 7152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T107630 WP_004098919.1 NZ_CP030314:168252-168734 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T107630 NZ_CP030314:168252-168734 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10151.58 Da        Isoelectric Point: 4.5141

>AT107630 WP_004213599.1 NZ_CP030314:167998-168264 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRVLIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT107630 NZ_CP030314:167998-168264 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A7D3T1D0

References