Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3990109..3990728 Replicon chromosome
Accession NZ_CP030313
Organism Klebsiella pneumoniae strain 11311

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag DRA79_RS19295 Protein ID WP_002892050.1
Coordinates 3990510..3990728 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag DRA79_RS19290 Protein ID WP_002892066.1
Coordinates 3990109..3990483 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRA79_RS19280 (DRA79_19765) 3985261..3986454 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DRA79_RS19285 (DRA79_19770) 3986477..3989623 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
DRA79_RS19290 (DRA79_19775) 3990109..3990483 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
DRA79_RS19295 (DRA79_19780) 3990510..3990728 + 219 WP_002892050.1 HHA domain-containing protein Toxin
DRA79_RS19300 (DRA79_19785) 3990887..3991453 + 567 WP_002892030.1 maltose O-acetyltransferase -
DRA79_RS19305 3991425..3991565 - 141 WP_004147370.1 hypothetical protein -
DRA79_RS19310 (DRA79_19790) 3991586..3992056 + 471 WP_002892026.1 YlaC family protein -
DRA79_RS19315 (DRA79_19795) 3992031..3993482 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
DRA79_RS19320 (DRA79_19800) 3993583..3994281 + 699 WP_032414604.1 GNAT family protein -
DRA79_RS19325 (DRA79_19805) 3994278..3994418 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
DRA79_RS19330 (DRA79_19810) 3994418..3994681 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T107623 WP_002892050.1 NZ_CP030313:3990510-3990728 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T107623 NZ_CP030313:3990510-3990728 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT107623 WP_002892066.1 NZ_CP030313:3990109-3990483 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT107623 NZ_CP030313:3990109-3990483 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References