Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 781028..781685 Replicon chromosome
Accession NZ_CP030313
Organism Klebsiella pneumoniae strain 11311

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag DRA79_RS03870 Protein ID WP_002916310.1
Coordinates 781275..781685 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DRA79_RS03865 Protein ID WP_002916312.1
Coordinates 781028..781294 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRA79_RS03840 (DRA79_03975) 776184..777617 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
DRA79_RS03845 (DRA79_03980) 777736..778464 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
DRA79_RS03850 (DRA79_03985) 778514..778825 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
DRA79_RS03855 (DRA79_03990) 778989..779648 + 660 WP_002916317.1 hemolysin III family protein -
DRA79_RS03860 (DRA79_03995) 779799..780782 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
DRA79_RS03865 (DRA79_04000) 781028..781294 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DRA79_RS03870 (DRA79_04005) 781275..781685 + 411 WP_002916310.1 protein YgfX Toxin
DRA79_RS03875 (DRA79_04010) 781692..782213 - 522 WP_002916308.1 flavodoxin FldB -
DRA79_RS03880 (DRA79_04015) 782314..783210 + 897 WP_064153067.1 site-specific tyrosine recombinase XerD -
DRA79_RS03885 (DRA79_04020) 783233..783946 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DRA79_RS03890 (DRA79_04025) 783952..785685 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T107613 WP_002916310.1 NZ_CP030313:781275-781685 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T107613 NZ_CP030313:781275-781685 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT107613 WP_002916312.1 NZ_CP030313:781028-781294 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT107613 NZ_CP030313:781028-781294 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References